CAS 1195768-06-9: Dabrafenib mesylate

Description: Dabrafenib mesylate is a targeted anticancer medication primarily used in the treatment of certain types of melanoma, particularly those with BRAF V600E mutations. It is a small molecule inhibitor that selectively targets and inhibits the BRAF protein, which is involved in cell signaling pathways that regulate cell growth and division. The mesylate salt form enhances its solubility and stability, facilitating its use in clinical settings. Dabrafenib mesylate is typically administered orally and is often used in combination with other therapies, such as trametinib, to improve treatment efficacy. The compound is characterized by its ability to inhibit tumor growth and is associated with various side effects, including fever, fatigue, and skin reactions. Its pharmacokinetics indicate a relatively rapid absorption and a half-life that supports once or twice daily dosing. As with many targeted therapies, monitoring for adverse effects and therapeutic response is crucial during treatment.

Formula: C₂₃H₂₀F₃N₅O₂S₂·CH₄O₃S

InChI: InChI=1S/C23H20F3N5O2S2.CH4O3S/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25;1-5(2,3)4/h4-11,31H,1-3H3,(H2,27,28,29);1H3,(H,2,3,4)

InChI key: InChIKey=YKGMKSIHIVVYKY-UHFFFAOYSA-N

SMILES: O=S(=O)(O)C.O=S(=O)(NC=1C=CC=C(C1F)C=2N=C(SC2C=3N=C(N=CC3)N)C(C)(C)C)C=4C(F)=CC=CC4F

Synonyms:

• GSK 2118436 methanesulfonate salt
• GSK 2118436B
• Benzenesulfonamide, N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-, methanesulfonate (1:1)
• N-[3-[5-(2-Aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide methanesulfonic acid
• Dabrafenib mesylate

Benzenesulfonamide, N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-, methanesulfonate (1:1)

CAS: 1195768-06-9

• Formula: C₂₄H₂₄F₃N₅O₅S₃
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 615.6681

Dabrafenib Mesilate

CAS: 1195768-06-9

• Color and Shape: Neat

Dabrafenib Mesylate

CAS: 1195768-06-9

• Formula: C₂₃H₂₀F₃N₅O₂S₂·CH₄O₃S
• Molecular weight: 519.56. 96.10

Dabrafenib Mesylate

CAS: 1195768-06-9

Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E …

• Formula: C₂₄H₂₄F₃N₅O₅S₃
• Purity: 99.45% - 99.62%
• Color and Shape: Solid
• Molecular weight: 615.67

Dabrafenib Mesylate

CAS: 1195768-06-9

Stability Hygroscopic Applications Dabrafenib is an inhibitor of mutated BRAF kinase and has clinical activity …

• Formula: C₂₃H₂₀F₃N₅O₂S₂·CH₄O₃S
• Color and Shape: White
• Molecular weight: 615.67

Dabrafenib mesylate

CAS: 1195768-06-9

Inhibitor of B-Raf kinase mutant

• Formula: C₂₃H₂₀F₃N₅O₂S₂·CH₄O₃S
• Purity: Min. 95%
• Color and Shape: White/Off-White Solid
• Molecular weight: 615.67