CAS 1197300-24-5
:TGR5
Description:
TGR5, also known as G-protein coupled receptor 19 (GPCR19), is a receptor that plays a significant role in various physiological processes, particularly in metabolism and energy homeostasis. It is primarily activated by bile acids, which are important for digestion and absorption of fats. TGR5 is expressed in various tissues, including the gastrointestinal tract, immune cells, and brown adipose tissue, where it influences metabolic pathways. Activation of TGR5 has been associated with increased energy expenditure, improved insulin sensitivity, and modulation of inflammation. This receptor is of interest in the context of metabolic disorders, such as obesity and type 2 diabetes, as well as in liver diseases. Research into TGR5 is ongoing, with potential therapeutic applications being explored, particularly in the development of drugs targeting metabolic diseases. Its unique role in mediating the effects of bile acids makes it a valuable target for understanding and potentially treating metabolic dysregulation.
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Found 7 products.
TGR5 Receptor Agonist
CAS:TGR5 Receptor AgonistFormula:C18H14Cl2N2O2Purity:≥95%Molecular weight:361.223-(2-Chlorophenyl)-N-(4-Chlorophenyl)-N,5-Dimethylisoxazole-4-Carboxamide
CAS:3-(2-Chlorophenyl)-N-(4-Chlorophenyl)-N,5-Dimethylisoxazole-4-CarboxamideFormula:C18H14Cl2N2O2Purity:98%Molecular weight:361.223-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-1,2-oxazole-4-carboxamide
CAS:Formula:C18H14Cl2N2O2Purity:98%Color and Shape:SolidMolecular weight:361.2220TGR5 Receptor Agonist
CAS:TGR5 is a potent TGR5(GPCR19) agonist.Formula:C18H14Cl2N2O2Purity:99.93% - ≥95%Color and Shape:SolidMolecular weight:361.22TGR5 Receptor Agonist
CAS:3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamideFormula:C18H14Cl2N2O2Purity:98%Molecular weight:361.22TGR5 Receptor Agonist
CAS:TGR5 Receptor Agonist is a synthetic compound designed to activate the G protein-coupled bile acid receptor 1, commonly known as TGR5. This receptor is largely expressed in various tissues, including liver, brown adipose tissue, and the gastrointestinal tract. TGR5 agonists are derived through chemical synthesis, enabling precise modulation of biological pathways. The mechanism of action involves activation of the TGR5 receptor, which leads to downstream signaling cascades that enhance energy expenditure, improve insulin sensitivity, and exert anti-inflammatory effects.
Formula:C18H14Cl2N2O2Purity:Min. 95%Molecular weight:361.22 g/mol
