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CAS 120011-70-3

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Donepezil hydrochloride

Description:
Donepezil hydrochloride is a reversible inhibitor of the enzyme acetylcholinesterase, primarily used in the treatment of Alzheimer's disease and other cognitive disorders. It enhances cholinergic function by increasing the levels of acetylcholine in the brain, which is crucial for memory and learning. The compound is typically administered in its hydrochloride salt form, which improves its solubility and bioavailability. Donepezil hydrochloride is characterized by its molecular formula, which includes carbon, hydrogen, nitrogen, and oxygen atoms, and it has a specific molecular weight. The substance is usually presented as a white to off-white crystalline powder, and it is soluble in water and alcohol. Its pharmacokinetics indicate that it has a relatively long half-life, allowing for once-daily dosing. Common side effects may include gastrointestinal disturbances, insomnia, and muscle cramps. As with any medication, it is essential to use Donepezil hydrochloride under medical supervision to monitor for efficacy and potential adverse reactions.
Formula:C24H30ClNO3
InChI:InChI=1/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H
InChI key:InChIKey=XWAIAVWHZJNZQQ-UHFFFAOYSA-N
SMILES:O=C1C=2C(=CC(OC)=C(OC)C2)CC1CC3CCN(CC4=CC=CC=C4)CC3.Cl
Synonyms:
  • 1-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride
  • 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride
  • 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride (1:1)
  • 2,3-Dihydro-5,6-Dimethoxy-2-[[1-(Phenylmethyl)-4-Piperidinyl]Methyl]-1H-Inden-1-One Hydrochloride
  • 2,3-dihydro-5,6-dimethoxy-2-{[1-(phemylmethyl)-4-piperidinyl]methyl}-1H-indan-1-one HCL
  • 2-(1-Benzylpiperidin-4-ylmethyl)-5,6-dimethoxyindan-1-one hydrochloride
  • 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride (1:1)
  • Akos 226-31
  • Aricept
  • Aricept D
  • See more synonyms
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products per page.Found 22 products.
  • Donepezil HCl - Bio-X ™
    Biosynth
    + Info

    Donepezil HCl - Bio-X ™

    Controlled Product
    CAS:
    Donepezil HCl is a reversible inhibitor of acetylcholinesterase (AChE), a type of cholinesterase enzyme. Donepezil HCl temporarily binds to and blocks the active site of the enzyme, inhibiting the enzyme's ability to break down acetylcholine, a neurotransmitter involved in learning and memory. This increase in acetylcholine concentrations at cholinergic synapses helps improve cognitive function in patients with Alzheimer's disease. Donepezil HCl may also have a role in calcium signalling through interaction with sigma receptors in the endoplasmic reticulum (ER).
    Formula:C24H30ClNO3
    Purity:Min. 99 Area-%
    Color and Shape:Off-White Powder
    Molecular weight:415.95 g/mol

    Ref: 3D-BD164380

    10mg
    186.00€
  • CymitQuimica logo
    Japanese Pharmacopoeia
    + Info

    Donepezil Hydrochloride RS

    CAS:
    Color and Shape:White Solid Crystalline Powder

    Ref: 2K-1090500021

    450mg
    Discontinued
    Discontinued product