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CAS 120011-70-3

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Donepezil hydrochloride

Description:
Donepezil hydrochloride is a reversible inhibitor of the enzyme acetylcholinesterase, primarily used in the treatment of Alzheimer's disease and other cognitive disorders. It enhances cholinergic function by increasing the levels of acetylcholine in the brain, which is crucial for memory and learning. The compound is typically administered in its hydrochloride salt form, which improves its solubility and bioavailability. Donepezil hydrochloride is characterized by its molecular formula, which includes carbon, hydrogen, nitrogen, and oxygen atoms, and it has a specific molecular weight. The substance is usually presented as a white to off-white crystalline powder, and it is soluble in water and alcohol. Its pharmacokinetics indicate that it has a relatively long half-life, allowing for once-daily dosing. Common side effects may include gastrointestinal disturbances, insomnia, and muscle cramps. As with any medication, it is essential to use Donepezil hydrochloride under medical supervision to monitor for efficacy and potential adverse reactions.
Formula:C24H30ClNO3
InChI:InChI=1/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H
InChI key:InChIKey=XWAIAVWHZJNZQQ-UHFFFAOYSA-N
SMILES:O=C1C=2C(=CC(OC)=C(OC)C2)CC1CC3CCN(CC4=CC=CC=C4)CC3.Cl
Synonyms:
  • 1-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride
  • 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride
  • 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride (1:1)
  • 2,3-Dihydro-5,6-Dimethoxy-2-[[1-(Phenylmethyl)-4-Piperidinyl]Methyl]-1H-Inden-1-One Hydrochloride
  • 2,3-dihydro-5,6-dimethoxy-2-{[1-(phemylmethyl)-4-piperidinyl]methyl}-1H-indan-1-one HCL
  • 2-(1-Benzylpiperidin-4-ylmethyl)-5,6-dimethoxyindan-1-one hydrochloride
  • 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride (1:1)
  • Akos 226-31
  • Aricept
  • Aricept D
  • See more synonyms
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