CAS 1204144-28-4
:AZD-1208
Description:
AZD-1208 is a small molecule inhibitor primarily targeting the protein kinase activity of the enzyme PIM (Proviral Integration site for Moloney murine leukemia virus). It has been investigated for its potential therapeutic applications in oncology, particularly in the treatment of various cancers where PIM kinases are implicated in tumor growth and survival. AZD-1208 exhibits characteristics typical of kinase inhibitors, including the ability to disrupt signaling pathways that promote cell proliferation and inhibit apoptosis. Its chemical structure includes specific functional groups that facilitate binding to the ATP-binding site of PIM kinases, thereby inhibiting their activity. The compound has undergone preclinical studies to evaluate its efficacy and safety profile, showing promise in combination therapies. As with many investigational drugs, its pharmacokinetics, bioavailability, and metabolic pathways are critical areas of research to determine optimal dosing regimens and potential side effects. Overall, AZD-1208 represents a targeted approach in cancer therapy, focusing on the modulation of specific signaling pathways to achieve therapeutic benefits.
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Found 9 products.
(5Z)-5-({2-[(3R)-3-Aminopiperidin-1-yl]-3-phenylphenyl}methylidene)-1,3-thiazolidine-2,4-dione
CAS:Formula:C21H21N3O2SPurity:98%Color and Shape:SolidMolecular weight:379.4753(R,Z)-5-((2-(3-Aminopiperidin-1-Yl)-[1,1'-Biphenyl]-3-Yl)Methylene)Thiazolidine-2,4-Dione
CAS:(R,Z)-5-((2-(3-Aminopiperidin-1-Yl)-[1,1'-Biphenyl]-3-Yl)Methylene)Thiazolidine-2,4-DionePurity:98%Molecular weight:379.48g/molAZD1208
CAS:<p>AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.</p>Formula:C21H21N3O2SPurity:97.24% - 99.83%Color and Shape:SolidMolecular weight:379.48AZD1208
CAS:Controlled Product<p>Applications AZD1208 is a potent, and orally available Pim kinase inhibitor.<br>References Dakin, L., et al.: Bioorg. Med. Chem. Lett., 22, 4599 (2012)<br></p>Formula:C21H21N3O2SColor and Shape:NeatMolecular weight:379.48AZD 1208
CAS:<p>Inhibits proto-oncogene Pim kinases (Pim-1, Pim-2 and Pim-3); antineoplastic</p>Formula:C21H21N3O2SPurity:Min. 95%Color and Shape:PowderMolecular weight:379.48 g/mol
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![(R,Z)-5-((2-(3-Aminopiperidin-1-Yl)-[1,1'-Biphenyl]-3-Yl)Methylene)Thiazolidine-2,4-Dione](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F54%2Fthumb%2FOR1025702.jpg&w=3840&q=75)
