CAS 1206101-20-3

GLPG0634

CAS: 1206101-20-3

Formula: C₂₃H₁₈N₆O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 410.4280

Ref: IN-DA008TGH

GLPG0634 analog

CAS: 1206101-20-3

GLPG0634 analog

Purity: ≥98%

Molecular weight: 410.43g/mol

Ref: 54-BUP08366

GLPG0634 analog

CAS: 1206101-20-3

GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.

Formula: C₂₃H₁₈N₆O₂

Purity: 99.52% - >99.99%

Color and Shape: Solid

Molecular weight: 410.43

Ref: TM-T3076

N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

Controlled Product

CAS: 1206101-20-3

Formula: C₂₃H₁₈N₆O₂

Color and Shape: Neat

Molecular weight: 410.428

Ref: TR-C982190

GLPG0634 analogue

CAS: 1206101-20-3

GLPG0634 is a potent inhibitor of the enzyme toll-like receptor (TLR) 4, and it has been shown to show anti-inflammatory activity in vitro. GLPG0634 is currently being investigated for its potential therapeutic effects in bowel disease and arthritis. GLPG0634 binds to TLR4, which is located on the surface of cells, inhibiting the activation of these cells by bacterial products or other agents that stimulate TLRs. This inhibition may be due to the suppression of cytokine production from immune cells such as monocytes and macrophages. The drug also inhibits pro-inflammatory responses mediated by Toll-like receptor 2 signalling pathways, such as those induced by lipopolysaccharide (LPS). GLPG0634 has been found to be effective against LPS-induced inflammation in vivo, with a potency comparable to that seen in vitro.

Formula: C₂₃H₁₈N₆O₂

Purity: Min. 95%

Molecular weight: 410.43 g/mol

Ref: 3D-GYB10120