CAS 1211441-98-3

LEE 011

Description:

LEE 011, with the CAS number 1211441-98-3, is a chemical compound that functions primarily as a selective inhibitor of cyclin-dependent kinase 4 and 6 (CDK4/6). This inhibition plays a crucial role in regulating the cell cycle, particularly in the transition from the G1 phase to the S phase, thereby impacting cellular proliferation. LEE 011 is often studied in the context of cancer therapy, as it has shown potential in treating various types of tumors, especially those that are hormone receptor-positive. The compound is characterized by its ability to induce cell cycle arrest in cancer cells, leading to reduced tumor growth. Additionally, it is typically administered in a pharmaceutical formulation, and its efficacy and safety profile are evaluated through clinical trials. As with many targeted therapies, understanding its mechanism of action and potential side effects is essential for optimizing its use in clinical settings.

Formula: C₂₃H₃₀N₈O

InChI: InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)

InChI key: InChIKey=RHXHGRAEPCAFML-UHFFFAOYSA-N

SMILES: C(N(C)C)(=O)C=1N(C=2C(C1)=CN=C(NC3=CC=C(C=N3)N4CCNCC4)N2)C5CCCC5

Synonyms:

• 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
• 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-
• Lee 011A
• Ribociclib
• Ribociclib (LEE011)
• LEE 011
• Kisqali.
• 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyri
• LEE 011 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
• 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
• LEE011, >=98%
• LEE-011,Ribociclib,LEE011
• 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE
• 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide LEE 011
• LEE 011; LEE-011;RIBOCICLIB;LEE011
• LEE011; LEE-011. LEE 011; RIBOCICLIB; KISQALI.
• Ribociclib USP/EP/BP
• CS-1001
• Ribociclib-d8
• LEE-011, Ribociclib
• 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidi
• LEE01
• LEE-011. LEE 011

7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

CAS: 1211441-98-3

Formula: C₂₃H₃₀N₈O

Purity: 98%

Color and Shape: Solid

Molecular weight: 434.5373

Ref: IN-DA003AC4

Ribociclib

CAS: 1211441-98-3

Formula: C₂₃H₃₀N₈O

Molecular weight: 434.55

Ref: 4Z-R-128001

7-Cyclopentyl-N,N-Dimethyl-2-((5-(Piperazin-1-Yl)Pyridin-2-Yl)Amino)-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxamide

CAS: 1211441-98-3

7-Cyclopentyl-N,N-Dimethyl-2-((5-(Piperazin-1-Yl)Pyridin-2-Yl)Amino)-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxamide

Purity: 98%

Molecular weight: 434.54g/mol

Ref: 54-OR1026670

Ribociclib

CAS: 1211441-98-3

Ribociclib

Purity: ≥95%

Molecular weight: 434.54g/mol

Ref: 54-BUP16959

Ribociclib

CAS: 1211441-98-3

Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor (IC50：10/39 nM).

Formula: C₂₃H₃₀N₈O

Purity: 97.91% - >99.99%

Color and Shape: Solid

Molecular weight: 434.54

Ref: TM-T6199

LEE011

CAS: 1211441-98-3

Ref: 7W-GW0606

Ribociclib-d8

CAS: 1211441-98-3

Formula: C₂₃H₂₂D₈N₈O

Molecular weight: 442.60

Ref: 4Z-R-128003

LEE 011

CAS: 1211441-98-3

Formula: C₂₃H₃₀N₈O

Ref: TR-TRC-L178830

LEE 011

Controlled Product

CAS: 1211441-98-3

Applications LEE 011 can be used in biological study of kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer.
References Jansen, V. M., et al.: Cancer Research, 77, 2488 (2017)

Formula: C₂₃H₃₀N₈O

Color and Shape: Light Yellow To Beige

Molecular weight: 434.54

Ref: TR-L178830

Ribociclib

CAS: 1211441-98-3

Inhibitor of CDK4/6 serine/threonine kinases; antineoplastic

Formula: C₂₃H₃₀N₈O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 434.54 g/mol

Ref: 3D-FR106414