CAS 121268-17-5: Alendronate monosodium trihydrate
Description:Alendronate monosodium trihydrate is a bisphosphonate compound primarily used in the treatment of osteoporosis and other bone-related disorders. It functions by inhibiting osteoclast-mediated bone resorption, thereby increasing bone mineral density. This compound is characterized by its molecular formula, which includes sodium and water molecules, indicating its hydrated form. Alendronate monosodium trihydrate is typically a white to off-white crystalline powder, soluble in water but poorly soluble in organic solvents. Its stability is influenced by pH, with optimal activity observed in slightly acidic to neutral conditions. The compound is administered orally, and its pharmacokinetics involve significant absorption in the gastrointestinal tract, although it is subject to first-pass metabolism. Side effects may include gastrointestinal disturbances and potential renal implications, necessitating careful monitoring during treatment. Overall, Alendronate monosodium trihydrate plays a crucial role in managing conditions associated with bone density loss, contributing to improved patient outcomes in osteoporosis management.
Formula:C4H13NO7P2·3H2O·Na
InChI:InChI=1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2
InChI key:InChIKey=PXPDLXULFWKPSB-UHFFFAOYSA-N
SMILES:[Na].O=P(O)(O)C(O)(CCCN)P(=O)(O)O.O
- Synonyms:
- (4-Amino-1-Hydroxybutane-1,1-Diyl)Bis(Phosphonic Acid)
- (4-Ammonio-1-Hydroxybutane-1,1-Diyl)Bis[Hydrogen (Phosphonate)]
- 4-Amino-1-Hydroxybutylidene-1,1-Bisphosphonic Acid Monosodium Salt Trihydrate
- Alendronate monosodium trihydrate
- Alendronate sodium hydrate
- Alendronic Acid Monosodium Salt Trihydrate
- Alendros Trihydrate
- Bifosa Trihydrate
- Fosalan Trihydrate
- Fosamaxtrihydrate
- See more synonyms
- Mandeloeltrihydrate
- Monosodium Alendronatetrihydrate
- Monosodium alendronate trihydrate
- Neobon Trihydrate
- Osteovan Trihydrate
- Phosphonic acid, (4-amino-1-hydroxybutylidene)bis-, monosodium salt, trihydrate
- Phosphonic acid, P,P′-(4-amino-1-hydroxybutylidene)bis-, sodium salt, hydrate (1:1:3)
- Sodium Hydrogen (4-Amino-1-Hydroxy-1-Phosphonobutyl)Phosphonate
- Sodium Hydrogen (4-Amino-1-Hydroxy-1-Phosphonobutyl)Phosphonate Hydrate (1:1:3)
- Sodium alendronate hydrate
- Teiroc
- Tetrasodium (4-Amino-1-Hydroxybutane-1,1-Diyl)Bis(Phosphonate)
