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CAS 1214-79-5

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5-(N,N-DIMETHYL)-AMILORIDE HYDROCHLORIDE

Description:
5-(N,N-Dimethyl)-amiloride hydrochloride is a synthetic compound primarily known for its role as a potassium-sparing diuretic. It is a derivative of amiloride, which is used in the treatment of hypertension and heart failure. The compound exhibits a high affinity for epithelial sodium channels (ENaC), inhibiting sodium reabsorption in the kidneys, thereby promoting diuresis while minimizing potassium loss. This characteristic makes it valuable in clinical settings, particularly for patients at risk of hypokalemia. The hydrochloride salt form enhances its solubility in water, facilitating its administration. In terms of physical properties, it is typically a white to off-white crystalline powder. The compound is stable under standard conditions but should be stored in a cool, dry place, protected from light. Its pharmacological profile includes potential side effects such as gastrointestinal disturbances and electrolyte imbalances, necessitating careful monitoring during therapeutic use. Overall, 5-(N,N-Dimethyl)-amiloride hydrochloride is an important agent in managing fluid balance and blood pressure in various medical conditions.
Formula:C8H12ClN7O
InChI:InChI=1/C8H12ClN7O/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12/h1-2H3,(H2,10,14)(H4,11,12,15,17)
InChI key:RXMUPNVSYKGKMY-UHFFFAOYSA-N
SMILES:CN(C)c1c(Cl)nc(c(N)n1)C(=NC(=N)N)O
Synonyms:
  • 5-Dimethylamiloride
  • Dma Hydrochloride
  • 5-(N,N-Dimethyl)Amiloride Hcl
  • Amiloride, 5-(N,N-Dimethyl)-, Hydrochloride
  • 3-Amino-N-(Aminoiminomethyl)-5-(Dimethylamino)-6-Chloro-Pyrazine-Carboxamide Hydrochloride
  • 5-(N,N-Dimethyl)-amiloride
  • 3-Amino-N-(Aminoiminoethyl)-5-(Dimethylamino)-6-Chloropyrazinecarboxamide Hydrochloride
  • 3-amino-6-chloro-N-(diaminomethylidene)-5-(dimethylamino)pyrazine-2-carboxamide
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