CAS 1217486-61-7

Alpelisib

Description:

Alpelisib is a selective inhibitor of the phosphatidylinositol 3-kinase (PI3K) pathway, specifically targeting the alpha isoform of PI3K. It is primarily used in the treatment of certain types of breast cancer, particularly those that are hormone receptor-positive and have mutations in the PIK3CA gene. Alpelisib functions by disrupting the signaling pathways that promote cancer cell growth and survival, thereby inhibiting tumor progression. The compound is administered orally and is often used in combination with other therapies, such as endocrine therapy, to enhance its efficacy. Its pharmacokinetics indicate a moderate half-life, allowing for once-daily dosing. Common side effects may include hyperglycemia, rash, and gastrointestinal disturbances, necessitating monitoring during treatment. Alpelisib's development represents a significant advancement in targeted cancer therapies, providing a more personalized approach to treatment based on genetic profiling of tumors.

Formula: C₁₉H₂₂F₃N₅O₂S

InChI: InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1

InChI key: InChIKey=STUWGJZDJHPWGZ-LBPRGKRZSA-N

SMILES: CC1=C(C=2C=C(C(C(F)(F)F)(C)C)N=CC2)SC(NC(=O)N3[C@H](C(N)=O)CCC3)=N1

Synonyms:

• (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
• (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-pyridin-4-yl]thiazol-2-yl]amide
• BYL 719
• 1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)-
• (S)-Pyrrolidine-1,2- dicarboxylic acid 2-amide- 1-([4-methyl-5-[2-(2,2,2-trifluoro-l,l-dimethyl-ethyl)-pyridin-4- yl]-thiazol-2-yl]-amide)

1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)-

CAS: 1217486-61-7

Formula: C₁₉H₂₂F₃N₅O₂S

Purity: 99%

Color and Shape: Solid

Molecular weight: 441.4705

Ref: IN-DA0015PI

Alpelisib

CAS: 1217486-61-7

Alpelisib

Purity: ≥98%

Molecular weight: 441.47g/mol

Ref: 54-BUP15013

Alpelisib

CAS: 1217486-61-7

Formula: C₁₉H₂₂F₃N₅O₂S

Molecular weight: 441.47

Ref: 4Z-A-359001

Alpelisib

CAS: 1217486-61-7

Formula: C₁₉H₂₂F₃N₅O₂S

Purity: ≥ 95.0%

Color and Shape: White to off-white powder

Molecular weight: 441.5

Ref: 7W-GW0189

Alpelisib

CAS: 1217486-61-7

Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.

Formula: C₁₉H₂₂F₃N₅O₂S

Purity: 98% - 99.73%

Color and Shape: Solid

Molecular weight: 441.47

Ref: TM-T1921

Alpelisib-d3,15N

CAS: 1217486-61-7

Formula: C₁₉H₁₉D₃F₃N₄₁₅NO₂S

Molecular weight: 445.48

Ref: 4Z-A-359002

Alpelisib-d3,15N2

CAS: 1217486-61-7

Formula: C₁₉H₁₉D₃F₃N₃₁₅N₂O₂S

Molecular weight: 446.48

Ref: 4Z-A-359003

BYL 719

CAS: 1217486-61-7

A selective inhibitor of PI3Kα. Inhibits cancer cell proliferation by blocking the G0/G1 phase of the cell cycle. Anti-tumor effect of BYL 719 has been demonstrated in models of tumors with PI3KCA mutation and amplification in vivo. BYL 719 also suppresses tumor growth in pre-clinical models of osteosarcoma.

Formula: C₁₉H₂₂F₃N₅O₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 441.47 g/mol

Ref: 3D-FP71607

Alpelisib-D7

Controlled Product

CAS: 1217486-61-7

Formula: C₁₉D₇H₁₅F₃N₅O₂S

Color and Shape: Neat

Molecular weight: 448.514

Ref: TR-A963201

Alpelisib

CAS: 1217486-61-7

Formula: C₁₉H₂₂F₃N₅O₂S

Molecular weight: 441.47

Ref: ST-EA-CP-A74000