CAS: 1217486-61-7 - Alpelisib

Formula: C₁₉H₂₂F₃N₅O₂S

InChI: InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1

InChI key: InChIKey=STUWGJZDJHPWGZ-LBPRGKRZSA-N

SMILES: O=C(N)C1N(C(=O)NC2=NC(=C(S2)C=3C=CN=C(C3)C(C)(C)C(F)(F)F)C)CCC1

Synonyms:

• (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
• (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-pyridin-4-yl]thiazol-2-yl]amide
• BYL 719
• 1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)-
• (S)-Pyrrolidine-1,2- dicarboxylic acid 2-amide- 1-([4-methyl-5-[2-(2,2,2-trifluoro-l,l-dimethyl-ethyl)-pyridin-4- yl]-thiazol-2-yl]-amide)

1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)-

CAS: 1217486-61-7

• Formula: C₁₉H₂₂F₃N₅O₂S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 441.4705

Alpelisib

CAS: 1217486-61-7

• Formula: C₁₉H₂₂F₃N₅O₂S
• Molecular weight: 441.47

Alpelisib-d3,15N2

CAS: 1217486-61-7

• Formula: C₁₉H₁₉D₃F₃N₃₁₅N₂O₂S
• Molecular weight: 446.48

Alpelisib

CAS: 1217486-61-7

Alpelisib

CAS: 1217486-61-7

Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.

• Formula: C₁₉H₂₂F₃N₅O₂S
• Purity: 98% - 99.73%
• Color and Shape: Solid
• Molecular weight: 441.47

Alpelisib-d3,15N

CAS: 1217486-61-7

• Formula: C₁₉H₁₉D₃F₃N₄₁₅NO₂S
• Molecular weight: 445.48

BYL 719

CAS: 1217486-61-7

A selective inhibitor of PI3Kα. Inhibits cancer cell proliferation by blocking the G0/G1 phase of …

• Formula: C₁₉H₂₂F₃N₅O₂S
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 441.47 g/mol

Alpelisib-D7

CAS: 1217486-61-7

• Formula: C₁₉D₇H₁₅F₃N₅O₂S
• Color and Shape: Neat
• Molecular weight: 448.514