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CAS 1217486-61-7

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Alpelisib

Description:
Alpelisib is a selective inhibitor of the phosphatidylinositol 3-kinase (PI3K) pathway, specifically targeting the alpha isoform of PI3K. It is primarily used in the treatment of certain types of breast cancer, particularly those that are hormone receptor-positive and have mutations in the PIK3CA gene. Alpelisib functions by disrupting the signaling pathways that promote cancer cell growth and survival, thereby inhibiting tumor progression. The compound is administered orally and is often used in combination with other therapies, such as endocrine therapy, to enhance its efficacy. Its pharmacokinetics indicate a moderate half-life, allowing for once-daily dosing. Common side effects may include hyperglycemia, rash, and gastrointestinal disturbances, necessitating monitoring during treatment. Alpelisib's development represents a significant advancement in targeted cancer therapies, providing a more personalized approach to treatment based on genetic profiling of tumors.
Formula:C19H22F3N5O2S
InChI:InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1
InChI key:InChIKey=STUWGJZDJHPWGZ-LBPRGKRZSA-N
SMILES:CC1=C(C=2C=C(C(C(F)(F)F)(C)C)N=CC2)SC(NC(=O)N3[C@H](C(N)=O)CCC3)=N1
Synonyms:
  • (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
  • (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-pyridin-4-yl]thiazol-2-yl]amide
  • BYL 719
  • 1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)-
  • (S)-Pyrrolidine-1,2- dicarboxylic acid 2-amide- 1-([4-methyl-5-[2-(2,2,2-trifluoro-l,l-dimethyl-ethyl)-pyridin-4- yl]-thiazol-2-yl]-amide)
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Found 13 products.