CAS 1218918-62-7

MK-7246

Description:

MK-7246 is a chemical compound that belongs to the class of small molecules, specifically designed as a selective antagonist of the prostaglandin D2 receptor 2 (DP2), which is implicated in various allergic and inflammatory conditions. This compound has garnered interest in the pharmaceutical industry for its potential therapeutic applications, particularly in treating asthma and other allergic diseases. MK-7246 exhibits a specific binding affinity for the DP2 receptor, which plays a crucial role in mediating the effects of prostaglandin D2, a lipid mediator involved in the inflammatory response. The compound's structure includes functional groups that enhance its receptor selectivity and bioavailability. Preclinical studies have indicated that MK-7246 may help reduce airway hyperresponsiveness and other symptoms associated with allergic reactions. However, as with any investigational drug, further clinical trials are necessary to fully understand its efficacy, safety profile, and potential side effects before it can be approved for widespread clinical use.

Formula: C₂₁H₂₁FN₂O₄S

InChI: InChI=1S/C21H21FN2O4S/c1-23(29(27,28)16-9-6-14(22)7-10-16)15-8-11-20-18(12-21(25)26)17-4-2-3-5-19(17)24(20)13-15/h2-7,9-10,15H,8,11-13H2,1H3,(H,25,26)/t15-/m1/s1

InChI key: JTCAGRAKUAAYDY-OAHLLOKOSA-N

SMILES: CN([C@@H]1CCC2=C(C3=CC=CC=C3N2C1)CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F

Synonyms:

• MK7246;MK 7246
• ethyl 2-(7-(4-fluoro-N-MethylphenylsulfonaMido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate
• 2-[(7R)-7-[(4-FLUOROPHENYL)SULFONYL-METHYLAMINO]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-10-YL]ACETIC ACID
• CS-2898
• Pyrido[1,2-a]indole-10-acetic acid, 7-[[(4-fluorophenyl)sulfonyl]methylamino]-6,7,8,9-tetrahydro-, (7R)-
• (7R)-7-[[(4-Fluorophenyl)sulfonyl]methylamino]-6,7,8,9-tetrahydropyrido[1,2-a]indole-10-acetic acid
• (R)-2-(7-(4-fluoro-N-MethylphenylsulfonaMido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid
• MK-7246
• MK7246;MK 7246;MK-7246

(R)-2-(7-(4-Fluoro-N-Methylphenylsulfonamide)-6,7,8,9-Tetrahydropyridine[1,2-A]Indole-10-Yl)Acetic Acid

CAS: 1218918-62-7

(R)-2-(7-(4-Fluoro-N-Methylphenylsulfonamide)-6,7,8,9-Tetrahydropyridine[1,2-A]Indole-10-Yl)Acetic Acid

Purity: 98%

Molecular weight: 416.47g/mol

Ref: 54-PC108467

(R)-2-(7-(4-Fluoro-N-methylphenylsulfonamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid

CAS: 1218918-62-7

Formula: C₂₁H₂₁FN₂O₄S

Purity: 97%

Molecular weight: 416.47

Ref: 10-F545906

MK-7246-d3

Controlled Product

CAS: 1218918-62-7

Formula: C₂₁D₃H₁₈FN₂O₄S

Color and Shape: Neat

Molecular weight: 419.484

Ref: TR-M425047

MK-7246

Controlled Product

CAS: 1218918-62-7

Formula: C₂₁H₂₁FN₂O₄S

Color and Shape: Neat

Molecular weight: 416.466

Ref: TR-M425045

MK-7246

CAS: 1218918-62-7

MK-7246 is a potent and specific CRTH2 antagonist (Ki: 2.5 nM).

Formula: C₂₁H₂₁FN₂O₄S

Color and Shape: Solid

Molecular weight: 416.466

Ref: TM-TQ0051

(7R)-7-[[(4-Fluorophenyl)sulfonyl]methylamino]-6,7,8,9-tetrahydropyrido[1,2-a]indole-10-acetic acid

CAS: 1218918-62-7

Formula: C₂₁H₂₁FN₂O₄S

Purity: 97%

Color and Shape: Solid

Molecular weight: 416.4658

Ref: IN-DA003AO3

MK-7246-d3

CAS: 1218918-62-7

MK-7246-d3 is a pancreas-selective β-cell receptor agonist that has been shown to have efficacy in the treatment of type 1 diabetes. The compound is able to inhibit the release of histamine from eosinophilic cells, which may be due to its ability to bind to histamine H1 receptors and inhibit calcium influx. MK-7246-d3 has also been shown to decrease acid secretion and increase bicarbonate secretion. These effects on the pancreas may be due to its ability to act as a potent antagonist at the gastric histamine H2 receptor. MK-7246-d3 has not yet been tested in humans but has shown promising results in vitro and in vivo animal models. This drug is also being evaluated for use in other diseases, such as chronic obstructive pulmonary disease, asthma, and rhinosinusitis.

Formula: C₂₁H₁₈D₃FN₂O₄S

Purity: Min. 95%

Molecular weight: 419.48 g/mol

Ref: 3D-TYB91862