CAS 1219168-18-9

Dorsomorphin 2HCl

Description:

Dorsomorphin 2HCl, with the CAS number 1219168-18-9, is a small molecule that acts as a selective inhibitor of the AMP-activated protein kinase (AMPK) pathway. This compound is characterized by its ability to modulate cellular energy homeostasis and has been studied for its potential therapeutic applications in metabolic disorders and cancer. Dorsomorphin is typically presented as a hydrochloride salt, which enhances its solubility in aqueous solutions, making it suitable for biological assays. The compound exhibits a relatively low molecular weight and possesses a specific chemical structure that allows it to interact selectively with AMPK, thereby influencing various metabolic processes. In research contexts, Dorsomorphin has been utilized to investigate the role of AMPK in cellular signaling, energy metabolism, and the regulation of glucose homeostasis. Its pharmacological properties and mechanism of action continue to be explored, highlighting its significance in the field of biochemistry and pharmacology.

Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-, hydrochloride (1:2)

CAS: 1219168-18-9

Formula: C₂₄H₂₇Cl₂N₅O

Purity: %

Color and Shape: Solid

Molecular weight: 472.4101

Ref: IN-DA0016E6

Dorsomorphin dihydrochloride

CAS: 1219168-18-9

Dorsomorphin dihydrochloride

Purity: ≥95%

Molecular weight: 472.41g/mol

Ref: 54-BUP13039

Dorsomorphin DiHCl

CAS: 1219168-18-9

Formula: C₂₄H₂₅N₅O·2HCl

Molecular weight: 399.50 2*36.46

Ref: 4Z-K-031033

Dorsomorphin dihydrochloride

CAS: 1219168-18-9

Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on

Formula: C₂₄H₂₅N₅O·2HCl

Purity: 97.74% - 99.89%

Color and Shape: Solid

Molecular weight: 472.41

Ref: TM-T6146

Dorsomorphin Dihydrochloride

Controlled Product

CAS: 1219168-18-9

Applications Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53.
References Shen, Q.W., Gerrard, D.E., Du, M.: Meat Sci., 78, 323 (2008); Yu, P., et. al.: Nat. Chem. Biol., 4, 33 (2008); Kim, H., et. al.: J. Biol. Chem., 283, 3731 (2008)

Formula: C₂₄H₂₅N₅O·2ClH

Color and Shape: Neat

Molecular weight: 472.41

Ref: TR-D534910

Dorsomorphin dihydrochloride

CAS: 1219168-18-9

Inhibitor of BMP pathway; inhibitor of ALK2 and ALK3 kinases

Formula: C₂₄H₂₇Cl₂N₅O

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 472.41 g/mol

Ref: 3D-BD162562