CAS 1219168-18-9
:Dorsomorphin 2HCl
Description:
Dorsomorphin 2HCl, with the CAS number 1219168-18-9, is a small molecule that acts as a selective inhibitor of the AMP-activated protein kinase (AMPK) pathway. This compound is characterized by its ability to modulate cellular energy homeostasis and has been studied for its potential therapeutic applications in metabolic disorders and cancer. Dorsomorphin is typically presented as a hydrochloride salt, which enhances its solubility in aqueous solutions, making it suitable for biological assays. The compound exhibits a relatively low molecular weight and possesses a specific chemical structure that allows it to interact selectively with AMPK, thereby influencing various metabolic processes. In research contexts, Dorsomorphin has been utilized to investigate the role of AMPK in cellular signaling, energy metabolism, and the regulation of glucose homeostasis. Its pharmacological properties and mechanism of action continue to be explored, highlighting its significance in the field of biochemistry and pharmacology.
Formula:C24H27Cl2N5O
InChI:InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20;;/h4-11,16-18H,1-3,12-15H2;2*1H
InChI key:RJDVIJJQKMGPMV-UHFFFAOYSA-N
SMILES:C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl
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Dorsomorphin dihydrochloride
CAS:Dorsomorphin dihydrochlorideFormula:C24H25N5O·2HClPurity:99%Color and Shape:SolidMolecular weight:472.41Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-, hydrochloride (1:2)
CAS:Formula:C24H27Cl2N5OPurity:99%Color and Shape:SolidMolecular weight:472.4101Dorsomorphin dihydrochloride
CAS:Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity onFormula:C24H25N5O·2HClPurity:97.74% - 99.89%Color and Shape:SolidMolecular weight:472.416-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine dihydrochloride
CAS:6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine dihydrochlorideFormula:C24H27Cl2N5OPurity:99+%Molecular weight:472.41Dorsomorphin Dihydrochloride
CAS:Controlled ProductApplications Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53.
References Shen, Q.W., Gerrard, D.E., Du, M.: Meat Sci., 78, 323 (2008); Yu, P., et. al.: Nat. Chem. Biol., 4, 33 (2008); Kim, H., et. al.: J. Biol. Chem., 283, 3731 (2008)Formula:C24H25N5O·2ClHColor and Shape:NeatMolecular weight:472.41Dorsomorphin dihydrochloride
CAS:Inhibitor of BMP pathway; inhibitor of ALK2 and ALK3 kinasesFormula:C24H27Cl2N5OPurity:Min. 95%Color and Shape:White To Off-White SolidMolecular weight:472.41 g/mol
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