CAS 122111-05-1

4-Amino-1-(2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone Hydrochloride

Description:

4-Amino-1-(2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone hydrochloride is a synthetic nucleoside analog with notable antiviral properties, particularly against viral infections such as HIV. This compound features a pyrimidinone base linked to a modified sugar moiety, which enhances its stability and bioavailability. The presence of difluorination in the sugar component contributes to its unique pharmacological profile, potentially improving its efficacy and selectivity. As a hydrochloride salt, it is typically more soluble in aqueous solutions, facilitating its use in pharmaceutical formulations. The compound's structure allows it to interfere with nucleic acid synthesis in viral replication processes, making it a candidate for therapeutic applications. In terms of safety and handling, like many chemical substances, it should be managed with appropriate precautions due to its biological activity. Overall, this compound exemplifies the ongoing efforts in medicinal chemistry to develop effective antiviral agents through structural modifications of nucleoside analogs.

Formula: C₉H₁₂ClF₂N₃O₄

InChI: InChI=1/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6+,7+;/m1./s1

Synonyms:

• 1’-Epi Gemcitabine Hydrochloride

Gemcitabine EP Impurity B-13C-15N2 HCl (α-Gemcitabine-13C-15N2 HCl)

CAS: 122111-05-1

Formula: C₈₁₃CH₁₁F₂N₁₅N₂O₄·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 266.18 36.46

Ref: 4Z-G-268

Gemcitabine EP Impurity B HCl (Gemcitabine α-Isomer HCl)

CAS: 122111-05-1

Formula: C₉H₁₁F₂N₃O₄·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 263.20 36.46

Ref: 4Z-G-266

1''-Epi gemcitabine hydrochloride

CAS: 122111-05-1

Ref: 7W-GN6619

1’-Epi Gemcitabine Hydrochloride

CAS: 122111-05-1

Impurity Gemcitabine EP Impurity B
Applications 1’-Epi Gemcitabine Hydrochloride (Gemcitabine EP Impurity B) is an α-Anomer of Gemcitabine.
References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),

Formula: C₉H₁₂ClF₂N₃O₄

Color and Shape: Off White Solid

Molecular weight: 299.66

Ref: TR-E588510

1’-Epi Gemcitabine-13C,15N2 Hydrochloride

Controlled Product

CAS: 122111-05-1

Applications α-Anomer of labelled Gemcitabine.
References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),

Formula: C₈CH₁₂ClF₂NN₂O₄

Color and Shape: Neat

Molecular weight: 302.64

Ref: TR-E588512

1'-Epi gemcitabine, hydrochloride

CAS: 122111-05-1

Gemcitabine hydrochloride is an analog of the natural nucleoside cytidine. It is a chemotherapeutic drug that is used in the treatment of pancreatic, lung and breast cancer. Gemcitabine hydrochloride is metabolized to its active form by deamination of cytosine residues in DNA. This conversion is catalyzed by the enzyme cytidine deaminase. Gemcitabine hydrochloride has been shown to be effective against metastatic pancreatic cancer and advanced-stage non-small cell lung cancer, as well as early-stage breast cancer. Gemcitabine hydrochloride has also been shown to be effective against certain types of lymphoma and leukemia.

Formula: C₉H₁₂ClF₂N₃O₄

Purity: Min. 95%

Molecular weight: 299.66 g/mol

Ref: 3D-IE16542