CAS 1222-05-5

Galaxolide

Description:

Galaxolide, with the CAS number 1222-05-5, is a synthetic musk compound widely used in the fragrance industry. It is characterized by its pleasant, musky odor, which resembles that of natural musk. Galaxolide is a colorless to pale yellow liquid at room temperature and is known for its stability and low volatility, making it suitable for use in various personal care products, detergents, and household items. The compound is lipophilic, allowing it to blend well with oils and fats, enhancing its effectiveness as a fragrance fixative. Galaxolide is generally regarded as safe for use in cosmetics, although its environmental impact has raised concerns due to its persistence in aquatic environments. It is classified as a polycyclic musk, which refers to a group of synthetic musks that can accumulate in the environment. Overall, Galaxolide's desirable scent profile and stability contribute to its popularity in fragrance formulations, while ongoing research continues to evaluate its ecological effects.

Formula: C₁₈H₂₆O

InChI: InChI=1S/C18H26O/c1-11-9-19-10-13-7-15-16(8-14(11)13)18(5,6)12(2)17(15,3)4/h7-8,11-12H,9-10H2,1-6H3

InChI key: InChIKey=ONKNPOPIGWHAQC-UHFFFAOYSA-N

SMILES: CC1(C)C=2C(=CC3=C(C2)COCC3C)C(C)(C)C1C

Synonyms:

• 1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8- HEXAMETHYL CYCLOPENTA-γ-2-BENZOPYRAN
• 1,3,4,6,7,8-Hexahidro-4,6,6,7,8,8-Hexametilindeno[5,6-C]Pirano
• 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-Hexamethylindeno(5,6-C)Pyr
• 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-Hexamethylindeno[5,6-C]Pyranne
• 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-gamma-2-benzopyran
• 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclo-penta[g]-2-benzo pyrane
• 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran
• 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyrane
• 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyrane
• 1,3,4,6,7,8-Hexahydro-4,6,6,8,8,8-hexamethylcyclopenta-2-benzopyran
• 1-[2-(Dimethylamino)-1-(4-Methoxyphenyl)Ethyl]Cyclohexanol Hydrochloride (1:1)
• 4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-Hexahydrocyclopenta[G]Isochromene
• Abbalide
• Cimalide 50
• Cyclopenta[g]-2-benzopyran, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-
• Galaxolide
• Galaxolide 50
• Galaxolide 50BB
• Galaxolide 50IPM
• Galaxolide Abbalide
• Galaxolide White
• Hhcb
• Pearlide
• Venlafaxine

1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran (ca. 50% in Diethyl Phthalate)

CAS: 1222-05-5

Formula: C₁₈H₂₆O

Color and Shape: Colorless to Light yellow clear liquid

Molecular weight: 258.41

Ref: 3B-G0415

Cyclopenta[g]-2-benzopyran, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-

CAS: 1222-05-5

Formula: C₁₈H₂₆O

Purity: 70%

Color and Shape: Liquid

Molecular weight: 258.3984

Ref: IN-DA0016XN

Galaxolide

CAS: 1222-05-5

Ref: 7W-GK3703

4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-Hexahydrocyclopenta[G]Isochromene

CAS: 1222-05-5

4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-Hexahydrocyclopenta[G]Isochromene

Purity: 70%

Molecular weight: 258.40g/mol

Ref: 54-OR1011338

Mix 1 of Musk a. Polycy. Musk Comp. 10 µg/mL in Cyclohexane

CAS: 105-95-3, 1222-05-5, 13171-00-1, 15323-35-0, 21145-77-7, 33704-61-9, 68140-48-7, 81-14-1, 81-15-2, 83-66-9

Formula: C₁₄H₂₂O

Color and Shape: Mixture

Molecular weight: 206.32

Ref: 04-LA19020100CY

HHCB

CAS: 1222-05-5

Formula: C₁₈H₂₆O

Color and Shape: Neat

Molecular weight: 258.40

Ref: 04-C14213000

HHCB 10 µg/mL in Isooctane

Controlled Product

CAS: 1222-05-5

Formula: C₁₈H₂₆O

Color and Shape: Colourless

Molecular weight: 258.40

Ref: 04-A14213000IO-10

Galaxolide

CAS: 1222-05-5

Formula: C₁₈H₂₆O

Molecular weight: 258.41

Ref: 4Z-G-159001

Galaxolide-13C-d2

CAS: 1222-05-5

Formula: CC₁₇H₂₄D₂O

Molecular weight: 261.41

Ref: 4Z-G-159002

Galaxolide-d6 (Mixture of Diastereomers) (>80%)

Controlled Product

CAS: 1222-05-5

Applications Galaxolide-d6 is the isotope labelled analog of Galaxolide (G189000); a polycyclic musk (PCM) used as a fragrance ingredient in perfumes, soaps, cosmetics and detergents.
References Mori, T. et al.: J. Health Sci., 52, 276 (2006); Chen Y. et al.: Flav. Frag. J., 21, 822 (2006)

Formula: C₁₈H₂₀D₆O

Purity: >80%

Color and Shape: Neat

Molecular weight: 264.43541

Ref: TR-G189002

Galaxolide (Mixture of Diastereomers)

Controlled Product

CAS: 1222-05-5

Stability Moisture sensitive
Applications Galaxolide is a polycyclic musk (PCM) used as a fragrance ingredient in perfumes, soaps, cosmetics and detergents. It is increasingly found in the Great Lakes. An assessment by Green-Screen for Safer Chemicals indicates that it is toxic to aquatic life.This compound is a contaminant of emerging concern (CECs).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mori, T. et al.: J. Health Sci., 52, 276 (2006); Chen Y., et al.: Flav. Frag. J., 21, 822 (2006); Chem. and Eng. News, May 2 (2016), page 19

Formula: C₁₈H₂₆O

Purity: >80%

Color and Shape: Colourless

Molecular weight: 258.40

Ref: TR-G189000

Galaxolide (solution 50% in diethyl phthalate)

Controlled Product

CAS: 1222-05-5

Applications Galaxolide is a polycyclic musk (PCM) used as a fragrance ingredient in perfumes, soaps, cosmetics and detergents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mori, T. et al.: J. Health Sci., 52, 276 (2006); Chen Y. et al.: Flav. Frag. J., 21, 822 (2006);

Formula: C₁₈H₂₆O

Color and Shape: Single Solution

Molecular weight: 258.40

Ref: TR-G189001

Galaxolide - Mixture of Diastereomers

CAS: 1222-05-5

Galaxolide is a mixture of diastereomers that has been shown to inhibit the growth of bacteria in wastewater treatment systems. It also has high resistance to oxidation and biological attack, which makes it an ideal candidate for use as an antimicrobial agent. Galaxolide exhibits strong inhibitory properties against bacterial membrane potentials and mitochondrial membrane potential, and displays antioxidant activity in vitro. The molecular docking analysis of galaxolide showed that it binds to the active site of triclosan-induced peroxidase. This binding inhibits the enzyme activity of this enzyme, which is responsible for oxidative injury in cells. The chemical structures of galaxolide have been determined using a variety of analytical methods, including dispersive solid-phase extraction with fluorescence detection.

Formula: C₁₈H₂₆O

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 258.4 g/mol

Ref: 3D-FG23642

Galaxolide-13C3 (Mixture of Diastereomers)

Controlled Product

CAS: 1222-05-5

Formula: C₃C₁₅H₂₆O

Color and Shape: Neat

Molecular weight: 261.38

Ref: TR-G189003

Galaxolide solution, 50% in diethyl phthalate

CAS: 1222-05-5

Galaxolide is a synthetic fragrance ingredient. It is a mixture of two isomers, alpha- and beta-galaxolide. Galaxolide has been shown to have antimicrobial properties and can be used in the treatment of wastewater. The analytical method for galaxolide includes dispersive solid phase extraction with benzalkonium chloride (BAC). The BAC forms an ionic complex with galaxolide that can then be extracted into organic solvent. Galaxolide also has high resistance to microbial degradation and can be used as an antimicrobial agent in cosmetics.

Formula: C₁₈H₂₆O

Purity: Min. 95%

Color and Shape: Clear Liquid

Molecular weight: 258.4 g/mol

Ref: 3D-FG45940

Galaxolide

CAS: 1222-05-5

Galaxolide can induce estrogenic activity (Estrogen Receptor/ERR), oxidative stress, and genotoxicity. It also stimulates the enzymatic activities of EROD and GST (Glutathione S-transferase).

Formula: C₁₈H₂₆O

Color and Shape: Solid

Molecular weight: 258.40

Ref: TM-T201465