CAS 1226499-98-4

N2,N4-Bis(2,3-diMethyl-2H-indazol-6-yl)-2,4-pyriMidinediaMine

Description:

N2,N4-Bis(2,3-diMethyl-2H-indazol-6-yl)-2,4-pyriMidinediaMine, with the CAS number 1226499-98-4, is a synthetic organic compound characterized by its complex structure, which includes multiple aromatic rings and nitrogen-containing functional groups. This compound features a pyrimidine backbone, which is a six-membered ring containing two nitrogen atoms, and is substituted with two indazole moieties. The presence of methyl groups on the indazole rings enhances its lipophilicity and may influence its biological activity. Typically, compounds of this nature are studied for their potential applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting various biological pathways. The specific interactions and reactivity of this compound would depend on its molecular conformation and the electronic properties imparted by its substituents. As with many nitrogen-rich heterocycles, it may exhibit interesting properties such as fluorescence or coordination with metal ions, making it a subject of interest in both organic synthesis and materials science.

Formula: C₂₂H₂₂N₈

Synonyms:

• Pazopanib Di-Indazole Impurity
• N2,N4-Bis(2,3-diMethyl-2H-indazol-6-yl)-2,4-pyriMidinediaMine

Pazopanib Impurity 50

CAS: 1226499-98-4

Formula: C₂₂H₂₂N₈

Molecular weight: 398.47

Ref: 4Z-P-129062

N2,N4-Bis(2,3-dimethyl-2H-indazol-6-yl)-2,4-pyrimidinediamine Hydrochloride

Controlled Product

CAS: 1226499-98-4

Applications N2,N4-bis(2,3-dimethyl-2Hindazol-6-yl)-2,4-pyrimidinediamine Hydrochloride is a Pazopanib (P210925) dimer impurity. Pazopanib is an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
References Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009); Li, Y. et al.: J. Pharm. Biomed. Anal., 52, 493 (2010);

Formula: C₂₂H₂₂N₈•xHCl

Color and Shape: Neat

Molecular weight: 398.463646

Ref: TR-B429846

N2,N4-Bis(2,3-dimethyl-2H-indazol-6-yl)-2,4-pyrimidinediamine

Controlled Product

CAS: 1226499-98-4

Formula: C₂₂H₂₂N₈

Color and Shape: Neat

Molecular weight: 398.464

Ref: TR-B429845

Pazopanib Dimer impurity

CAS: 1226499-98-4

Formula: C₂₂H₂₂N₈

Molecular weight: 398.47

Ref: ST-EA-CP-P58009