N2,N4-Bis(2,3-dimethyl-2H-indazol-6-yl)-2,4-pyrimidinediamine Hydrochloride

CAS:
1226499-98-4

Ref. TR-B429846

Product Information

Name:N2,N4-Bis(2,3-dimethyl-2H-indazol-6-yl)-2,4-pyrimidinediamine Hydrochloride

Controlled Product

Synonyms:

2-N,4-N-bis(2,3-dimethylindazol-6-yl)pyrimidine-2,4-diamine

Brand:TRC

Description:

Applications N2,N4-bis(2,3-dimethyl-2Hindazol-6-yl)-2,4-pyrimidinediamine Hydrochloride is a Pazopanib (P210925) dimer impurity. Pazopanib is an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
References Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009); Li, Y. et al.: J. Pharm. Biomed. Anal., 52, 493 (2010);

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Chemical properties

Molecular weight:398.463646

Formula:C₂₂H₂₂N₈•xHCl

Color/Form:Neat

InChI:InChI=1S/C22H22N8/c1-13-17-7-5-15(11-19(17)27-29(13)3)24-21-9-10-23-22(26-21)25-16-6-8-18-14(2)30(4)28-20(18)12-16/h5-12H,1-4H3,(H2,23,24,25,26)

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