CAS 1227666-13-8

NATEGLINIDE-PHENYL-D5

Description:

Nateglinide-phenyl-D5, identified by its CAS number 1227666-13-8, is a deuterated derivative of nateglinide, a medication primarily used in the management of type 2 diabetes. As a rapid-acting insulin secretagogue, it stimulates insulin release from the pancreas in response to meals, thereby helping to control postprandial blood glucose levels. The deuterated form, indicated by the "D5" in its name, suggests that it contains five deuterium atoms, which are isotopes of hydrogen. This modification can enhance the stability and metabolic tracking of the compound in pharmacokinetic studies. Nateglinide-phenyl-D5 retains the core structure of nateglinide, which includes a phenyl group and a carboxylic acid moiety, contributing to its biological activity. The presence of deuterium may also influence its pharmacological properties, such as absorption and elimination rates. Overall, this compound serves as a valuable tool in research, particularly in studies focused on drug metabolism and the pharmacodynamics of diabetes medications.

Formula: C₁₉H₂₂D₅NO₃

InChI: InChI=1S/C19H27NO3/c1-13(2)15-8-10-16(11-9-15)18(21)20-17(19(22)23)12-14-6-4-3-5-7-14/h3-7,13,15-17H,8-12H2,1-2H3,(H,20,21)(H,22,23)/t15?,16?,17-/m1/s1/i3D,4D,5D,6D,7D

InChI key: OELFLUMRDSZNSF-ZBRYERADSA-N

SMILES: [2H]C1=C(C(=C(C(=C1[2H])[2H])C[C@H](C(=O)O)NC(=O)C2CCC(CC2)C(C)C)[2H])[2H]

Synonyms:

• NATEGLINIDE-PHENYL-D5
• NATEGLINIDE-D5

Nateglinide-d5

CAS: 1227666-13-8

Nateglinide-d5

Formula: C₁₉H₂₂D₅NO₃

Purity: 98.0%

Molecular weight: 322.45

Ref: 54-DE3104

Nateglinide-d5

CAS: 1227666-13-8

Formula: C₁₉H₂₂D₅NO₃

Color and Shape: White To Off-White Solid

Molecular weight: 322.46

Ref: 4Z-N-021

Nateglinide-d5 (phenyl-d5)

CAS: 105816-04-4, 1227666-13-8

Purity: 99 atom % D

Color and Shape: White Solid

Molecular weight: 322.46

Ref: 3U-D6838

Nateglinide-D5

CAS: 1227666-13-8

Nateglinide D5 is a deuterium labeled Nateglinide.

Formula: C₁₉H₂₇NO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 322.4534

Ref: TM-T12178

Nateglinide-d5

Controlled Product

CAS: 1227666-13-8

Applications A labelled version of Nateglinide, an amino-acid derivative that stimulates insulin secretion which is used as an antidiabetic.
References Shinkai, H., et al.: J. Med. Chem., 32, 1436 (1989), Sato, Y., et al.: Diabetes Res. Clin. Pract., 12, 53 (1991), Vicent, D., et al.: J. Clin. Invest., 111, 1373 (2003), Ceriello, A., et al.: Diabet. Med., 21, 171 (2004),

Formula: C₁₉D₅H₂₂NO₃

Color and Shape: Neat

Molecular weight: 322.45

Ref: TR-N379377

Nateglinide D5

CAS: 1227666-13-8

Formula: C₁₉H₂₇NO₃

Molecular weight: 322.5

Ref: BE-RMCN036001