CAS 1227923-29-6

M1 receptor modulator

Description:

The chemical substance known as "M1 receptor modulator" with the CAS number 1227923-29-6 is primarily characterized by its role as a selective modulator of the muscarinic acetylcholine receptor subtype M1. This compound is of interest in pharmacological research, particularly for its potential therapeutic applications in treating cognitive deficits associated with conditions such as Alzheimer's disease and schizophrenia. M1 receptor modulators are designed to enhance the activity of the M1 receptor, which is involved in cognitive processes, without significantly affecting other muscarinic receptor subtypes, thereby minimizing side effects. These compounds typically exhibit high affinity for the M1 receptor and may influence various signaling pathways, including those related to neurotransmitter release and neuronal excitability. The development of M1 receptor modulators is part of a broader effort to create targeted treatments that improve cognitive function while reducing the risk of adverse effects commonly associated with non-selective muscarinic agents. As research continues, the understanding of their pharmacokinetics, efficacy, and safety profiles will be crucial for their potential clinical applications.

Synonyms:

• 3-[(1S,2S)-2-Hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]benzo[h]quinazolin-4(3H)-one
• M1 receptor
• MK-7622
• 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]quinazolin-4-one
• MK 7622

MK-7622

CAS: 1227923-29-6

MK-7622 (M1 receptor modulator) is a modulator of muscarinic M1 receptor positive allosteric.

Formula: C₂₅H₂₅N₃O₂

Purity: 99.77% - 99.8%

Color and Shape: Solid

Molecular weight: 399.48

Ref: TM-T15942

MK-7622

CAS: 1227923-29-6

MK-7622

Purity: ≥98%

Molecular weight: 399.48g/mol

Ref: 54-BUP05742

MK-7622

CAS: 1227923-29-6

MK-7622 is a quinazolinone that acts as a non-selective muscarinic acetylcholine receptor antagonist. It is also an allosteric modulator, which means that it binds to the allosteric site of the acetylcholine receptor and enhances its activity. This drug has been shown to have anticholinesterase properties in mice and rats, with efficacy at doses lower than those required for other established drugs. MK-7622 has been shown to improve cognitive functions in animal models of Alzheimer's disease, Parkinson's disease, and Huntington's disease. The mechanism of action is not fully understood but may be due to the inhibition of acetylcholinesterase activity by this drug.

Formula: C₂₅H₂₅N₃O₂

Purity: Min. 95%

Molecular weight: 399.48 g/mol

Ref: 3D-CZB92329