CAS 1228088-30-9

8-Chloro-5,6-dihydro-5-methyl-1-[trans-4-(2-pyridinyloxy)cyclohexyl]-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Description:

8-Chloro-5,6-dihydro-5-methyl-1-[trans-4-(2-pyridinyloxy)cyclohexyl]-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine is a synthetic compound that belongs to the benzodiazepine class, characterized by its complex structure which includes a triazole ring fused to a benzodiazepine framework. This compound features a chloro substituent and a pyridinyloxy group, which contribute to its pharmacological properties. Typically, benzodiazepines exhibit anxiolytic, sedative, and muscle relaxant effects, and the presence of the triazole moiety may enhance these activities or modify the compound's interaction with GABA receptors. The specific stereochemistry, particularly the trans configuration of the cyclohexyl group, can influence the compound's biological activity and receptor binding affinity. As with many synthetic pharmaceuticals, the solubility, stability, and bioavailability of this compound are critical for its potential therapeutic applications. Further studies would be necessary to elucidate its pharmacokinetics, pharmacodynamics, and safety profile.

Formula: C₂₂H₂₄ClN₅O

InChI: InChI=1/C22H24ClN5O/c1-27-13-16-12-17(23)7-10-19(16)28-20(14-27)25-26-22(28)15-5-8-18(9-6-15)29-21-4-2-3-11-24-21/h2-4,7,10-12,15,18H,5-6,8-9,13-14H2,1H3/t15-,18-

InChI key: InChIKey=GMPZPHGHNDMRKL-RZDIXWSQNA-N

SMILES: CN1CC=2N(C(=NN2)[C@@H]3CC[C@@H](OC4=CC=CC=N4)CC3)C=5C(C1)=CC(Cl)=CC5

Synonyms:

• RG 7314
• 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-5,6-dihydro-5-methyl-1-[trans-4-(2-pyridinyloxy)cyclohexyl]-
• RO 5285119
• Balovaptan
• 8-Chloro-5,6-dihydro-5-methyl-1-[trans-4-(2-pyridinyloxy)cyclohexyl]-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
• trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraazabenzo[e]azulene
• Balovaptan(RG7314)
• RG7314
• RG 7314,Vasopressin Receptor,RG-7314,inhibit,Inhibitor,Balovaptan

Balovaptan

CAS: 1228088-30-9

Balovaptan

Formula: C₂₂H₂₄ClN₅O

Purity: 99.5%

Molecular weight: 409.91

Ref: 54-BUP06142

8-Chloro-5-Methyl-1-((1R,4R)-4-(Pyridin-2-Yloxy)Cyclohexyl)-5,6-Dihydro-4H-Benzo[F][1,2,4]Triazolo[4,3-A][1,4]Diazepine

CAS: 1228088-30-9

8-Chloro-5-Methyl-1-((1R,4R)-4-(Pyridin-2-Yloxy)Cyclohexyl)-5,6-Dihydro-4H-Benzo[F][1,2,4]Triazolo[4,3-A][1,4]Diazepine

Formula: C₂₂H₂₄ClN₅O

Purity: 97%

Molecular weight: 409.91

Ref: 54-OR1024203

Balovaptan

CAS: 1228088-30-9

Balovaptan (RG7314), a potent brain-penetrant hV1a receptor antagonist, Ki: 1 nM for hV1a, aids autism research.

Formula: C₂₂H₂₄ClN₅O

Purity: 99.88%

Color and Shape: White Solid

Molecular weight: 409.912

Ref: TM-T14494

8-Chloro-5-Methyl-1-((1R,4R)-4-(Pyridin-2-Yloxy)Cyclohexyl)-5,6-Dihydro-4H-Benzo[F][1,2,4]Triazolo[4,3-A][1,4]Diazepine

CAS: 1228088-30-9

Formula: C₂₂H₂₄ClN₅O

Purity: 97%

Color and Shape: Solid

Molecular weight: 409.9119

Ref: IN-DA01FVJ7

Balovaptan

CAS: 1228088-30-9

8-Chloro-5-methyl-1-((1r,4r)-4-(pyridin-2-yloxy)cyclohexyl)-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine

Formula: C₂₂H₂₄ClN₅O

Purity: 97%

Molecular weight: 409.91

Ref: IN-DG00800823

Balovaptan

CAS: 1228088-30-9

Balovaptan is a drug that belongs to the class of pharmacological agents. It has shown clinical development for the treatment of symptoms related to disorders such as depression and anxiety. Balovaptan is a hydrogen-bond inhibitor that binds to the GABAA receptor and inhibits GABA-induced chloride ion flux, which results in an increase in neuronal excitability. This leads to increased levels of gamma-aminobutyric acid (GABA) and oxytocin, which are neurotransmitters that regulate brain activity. The active form of balovaptan is a geometric isomer that can be metabolized by cytochrome P450 enzymes, leading to decreased plasma concentrations and lower efficacy.

Formula: C₂₂H₂₄ClN₅O

Purity: Min. 95%

Molecular weight: 409.91 g/mol

Ref: 3D-DZB08830