CAS 1228817-38-6

Formula: C26H36N6O3

InChI: InChI=1S/C26H36N6O3/c1-3-35-23-16-19(31-13-10-20(33)11-14-31)8-9-21(23)28-26-27-17-22-25(29-26)32(18-6-4-5-7-18)15-12-24(34)30(22)2/h8-9,16-18,20,33H,3-7,10-15H2,1-2H3,(H,27,28,29)

InChI key: WELBJLUKWAJOQV-UHFFFAOYSA-N

SMILES: CCOC1=C(C=CC(=C1)N2CCC(CC2)O)NC3=NC=C4C(=N3)N(CCC(=O)N4C)C5CCCC5

9-Cyclopentyl-2-((2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5-methyl-5,7,8,9-tetrahydro-6H-pyrimido[4,5-b][1,4]diazepin-6-one

CAS: 1228817-38-6

9-Cyclopentyl-2-((2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5-methyl-5,7,8,9-tetrahydro-6H-pyrimido[4,5-b][1,4]diazepin-6-one

Formula: C₂₆H₃₆N₆O₃

Purity: 98%

Molecular weight: 480.61

Ref: 54-OR1073979

Mps1-IN-2

CAS: 1228817-38-6

Mps1-IN-2

Formula: C₂₆H₃₆N₆O₃

Purity: 99%

Molecular weight: 480.6

Ref: 54-BUP20412

Mps1-IN-2

CAS: 1228817-38-6

Purity: 98%

Ref: IN-DA009CDK

9-Cyclopentyl-2-((2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5-methyl-5,7,8,9-tetrahydro-6H-pyrimido[4,5-b][1,4]diazepin-6-one

CAS: 1228817-38-6

9-Cyclopentyl-2-((2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5-methyl-5,7,8,9-tetrahydro-6H-pyrimido[4,5-b][1,4]diazepin-6-one

Formula: C₂₆H₃₆N₆O₃

Purity: 98%

Molecular weight: 480.6

Ref: IN-DG630027

Mps1-IN-2

CAS: 1228817-38-6

Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.

Formula: C₂₆H₃₆N₆O₃

Purity: 96.24% - 99.75%

Color and Shape: Yellow Solid

Molecular weight: 480.6024

Ref: TM-T1839

Mps1-IN-2

CAS: 1228817-38-6

Mps1-IN-2 is a potent and selective inhibitor of the mitotic kinase Mps1. It binds to the ATP-binding site of Mps1 and inhibits its activity, leading to cell death by apoptosis or necrosis. Mps1-IN-2 has shown anti-tumor activity against cancer cells in vitro and in vivo without any significant side effects, making it an attractive candidate for cancer therapy. The crystal structure of Mps1-IN-2 bound to the kinase domain revealed that it binds to a pocket with high affinity, where ATP binding leads to conformational changes that affect the other domains of the enzyme. This study has also shown that Mps1-IN-2 inhibits spindle formation and cellular proliferation in cancer cells.

Formula: C₂₆H₃₆N₆O₃

Purity: Min. 95%

Molecular weight: 480.6 g/mol

Ref: 3D-DZB81738