CAS 1229236-86-5: Gandotinib

Description: Gandotinib is a small molecule inhibitor primarily designed to target specific kinases involved in cancer cell proliferation and survival. It is classified as a potent and selective inhibitor of the receptor tyrosine kinase, particularly focusing on the c-Met pathway, which plays a crucial role in various malignancies. The compound exhibits characteristics typical of kinase inhibitors, including the ability to disrupt signaling pathways that promote tumor growth and metastasis. Gandotinib's chemical structure includes functional groups that enhance its binding affinity to the target kinase, contributing to its efficacy in preclinical studies. It has been investigated for its potential therapeutic applications in treating various types of cancer, particularly those with aberrant c-Met signaling. As with many investigational drugs, its pharmacokinetics, safety profile, and effectiveness are subjects of ongoing research, with the aim of determining optimal dosing regimens and potential combination therapies. Overall, Gandotinib represents a promising avenue in targeted cancer therapy, reflecting the broader trend of developing selective agents to improve treatment outcomes.

Formula: C₂₃H₂₅ClFN₇O

InChI: InChI=1S/C23H25ClFN7O/c1-14-9-21(29-28-14)27-22-11-17(13-31-5-7-33-8-6-31)23-26-15(2)20(32(23)30-22)10-16-3-4-18(24)12-19(16)25/h3-4,9,11-12H,5-8,10,13H2,1-2H3,(H2,27,28,29,30)

InChI key: InChIKey=SQSZANZGUXWJEA-UHFFFAOYSA-N

SMILES: FC1=CC(Cl)=CC=C1CC2=C(N=C3C(=CC(=NN32)NC4=NNC(=C4)C)CN5CCOCC5)C

Imidazo[1,2-b]pyridazin-6-amine, 3-[(4-chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)-

CAS: 1229236-86-5

• Formula: C₂₃H₂₅ClFN₇O
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 469.9423

LY2784544

CAS: 1229236-86-5

Gandotinib

CAS: 1229236-86-5

LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).

• Formula: C₂₃H₂₅ClFN₇O
• Purity: 99.33% - 99.86%
• Color and Shape: Solid
• Molecular weight: 469.94

LY2784544

CAS: 1229236-86-5

• Formula: C₂₃H₂₅ClFN₇O
• Color and Shape: Neat
• Molecular weight: 469.942

LY 2784544

CAS: 1229236-86-5

Inhibitor of Janus kinase JAK2

• Formula: C₂₃H₂₅ClFN₇O
• Purity: Min. 95%
• Molecular weight: 469.94 g/mol