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Siponimod

CAS 1230487-00-9: Siponimod

Description:Siponimod is a synthetic compound primarily used in the treatment of multiple sclerosis, particularly for its ability to modulate the immune system. It functions as a sphingosine-1-phosphate receptor modulator, specifically targeting S1P receptors, which play a crucial role in lymphocyte trafficking and immune response. This mechanism helps to reduce the number of circulating lymphocytes, thereby mitigating inflammatory processes associated with multiple sclerosis. Siponimod is characterized by its relatively high oral bioavailability and a half-life that allows for once-daily dosing. The compound exhibits a favorable pharmacokinetic profile, with metabolism primarily occurring in the liver via cytochrome P450 enzymes. Its safety profile includes common side effects such as headache, hypertension, and elevated liver enzymes, necessitating monitoring during treatment. Overall, Siponimod represents a significant advancement in the therapeutic options available for managing multiple sclerosis, offering a targeted approach to disease modification.

Formula:C29H35F3N2O3

InChI:InChI=1S/C29H35F3N2O3/c1-3-21-14-23(10-11-24(21)15-34-16-25(17-34)28(35)36)19(2)33-37-18-20-9-12-26(22-7-5-4-6-8-22)27(13-20)29(30,31)32/h9-14,22,25H,3-8,15-18H2,1-2H3,(H,35,36)/b33-19+

InChI key:InChIKey=KIHYPELVXPAIDH-HNSNBQBZSA-N

SMILES:O=C(O)C1CN(CC2=CC=C(C=C2CC)C(=NOCC3=CC=C(C(=C3)C(F)(F)F)C4CCCCC4)C)C1

  • Synonyms:
  • 3-Azetidinecarboxylic acid, 1-[[4-[(1E)-1-[[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino]ethyl]-2-ethylphenyl]methyl]-
  • 1-[[4-[(1E)-1-[[[4-Cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino]ethyl]-2-ethylphenyl]methyl]-3-azetidinecarboxylic acid
  • BAF 312
  • Siponimod
  • 1-(4-[1-[(E)-4-Cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl]-2-ethyl-benzyl)-azetidine-3-carboxylic acid
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BAF-312(SiponiMod)

CAS:1230487-00-9

Ref: IN-DA009CK8

5mg91.00 €
25mg181.00 €
50mg281.00 €
100mg596.00 €
Estimated delivery in United States, on Tuesday 4 Mar 2025
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Ref: 4Z-S-146001

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Wednesday 5 Mar 2025
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Ref: 4Z-S-146002

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Tuesday 11 Mar 2025
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Siponimod

CAS:1230487-00-9

Ref: TM-T6403

2mg39.00 €
5mg57.00 €
10mg87.00 €
25mg139.00 €
50mg224.00 €
100mg310.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
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Siponimod

Controlled Product
CAS:1230487-00-9

Ref: TR-S683660

25mg424.00 €
2500µg126.00 €
Estimated delivery in United States, on Friday 14 Mar 2025
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Siponimod

CAS:1230487-00-9

Ref: 3D-FS103613

25mg292.00 €
50mg428.00 €
100mg740.00 €
250mg1,564.00 €
500mg2,507.00 €
Estimated delivery in United States, on Monday 17 Mar 2025
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Siponimod-D11

Controlled Product
CAS:1230487-00-9

Ref: TR-S683662

25mg52,793.00 €
Estimated delivery in United States, on Monday 14 Apr 2025
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Siponimod N-Oxide

Controlled Product
CAS:1230487-00-9

Ref: TR-S374890

10mg371.00 €
Estimated delivery in United States, on Monday 14 Apr 2025
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