CAS 1230487-00-9

Siponimod

Description:

Siponimod is a synthetic compound primarily used in the treatment of multiple sclerosis, particularly for its ability to modulate the immune system. It functions as a sphingosine-1-phosphate receptor modulator, specifically targeting S1P receptors, which play a crucial role in lymphocyte trafficking and immune response. This mechanism helps to reduce the number of circulating lymphocytes, thereby mitigating inflammatory processes associated with multiple sclerosis. Siponimod is characterized by its relatively high oral bioavailability and a half-life that allows for once-daily dosing. The compound exhibits a favorable pharmacokinetic profile, with metabolism primarily occurring in the liver via cytochrome P450 enzymes. Its safety profile includes common side effects such as headache, hypertension, and elevated liver enzymes, necessitating monitoring during treatment. Overall, Siponimod represents a significant advancement in the therapeutic options available for managing multiple sclerosis, offering a targeted approach to disease modification.

Formula:C₂₉H₃₅F₃N₂O₃

InChI:InChI=1S/C29H35F3N2O3/c1-3-21-14-23(10-11-24(21)15-34-16-25(17-34)28(35)36)19(2)33-37-18-20-9-12-26(22-7-5-4-6-8-22)27(13-20)29(30,31)32/h9-14,22,25H,3-8,15-18H2,1-2H3,(H,35,36)/b33-19+

InChI key:InChIKey=KIHYPELVXPAIDH-HNSNBQBZSA-N

SMILES:C(F)(F)(F)C1=C(C=CC(CO/N=C(\C)/C2=CC(CC)=C(CN3CC(C(O)=O)C3)C=C2)=C1)C4CCCCC4

Synonyms:

3-Azetidinecarboxylic acid, 1-[[4-[(1E)-1-[[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino]ethyl]-2-ethylphenyl]methyl]-
1-[[4-[(1E)-1-[[[4-Cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino]ethyl]-2-ethylphenyl]methyl]-3-azetidinecarboxylic acid
BAF 312
Siponimod
1-(4-[1-[(E)-4-Cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl]-2-ethyl-benzyl)-azetidine-3-carboxylic acid

Purity (%)

100

Found 12 products.

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(E)-1-(4-(1-(((4-Cyclohexyl-3-(Trifluoromethyl)Benzyl)Oxy)Imino)Ethyl)-2-Ethylbenzyl)Azetidine-3-Carboxylic Acid
CAS:
- 1230487-00-9
(E)-1-(4-(1-(((4-Cyclohexyl-3-(Trifluoromethyl)Benzyl)Oxy)Imino)Ethyl)-2-Ethylbenzyl)Azetidine-3-Carboxylic Acid
Formula:C₂₉H₃₅F₃N₂O₃
Purity:99%
Molecular weight:516.6
Ref: 54-PC108454
5mg
85.00€
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25mg
248.00€
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50mg
326.00€
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100mg
449.00€
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250mg
975.00€
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1g
2,217.00€
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BAF-312(SiponiMod)
CAS:
- 1230487-00-9
Formula:C₂₉H₃₅F₃N₂O₃
Purity:99%
Color and Shape:Solid
Molecular weight:516.5950
Ref: IN-DA009CK8
250mg
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1mg
55.00€
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5mg
91.00€
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25mg
171.00€
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50mg
264.00€
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100mg
574.00€
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Siponimod Trifluoroacetate
CAS:
- 1230487-00-9
- 1234627-85-0
Formula:C₂₉H₃₅F₃N₂O₃·C₂HF₃O₂
Molecular weight:516.61 114.02
Ref: 4Z-S-146001
5mg
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100mg
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10mg
436.00€
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25mg
623.00€
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50mg
810.00€
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Siponimod
CAS:
- 1230487-00-9
Siponimod
Formula:C₂₉H₃₅F₃N₂O₃
Purity:≥95%
Molecular weight:516.59
Ref: 54-BUP13132
2mg
53.00€
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5mg
83.00€
VAT not included
10mg
120.00€
VAT not included
25mg
202.00€
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50mg
324.00€
VAT not included
100mg
442.00€
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Siponimod-d5 Lithium Salt
CAS:
- 1230487-00-9
Formula:C₂₉H₂₉D₅F₃N₂O₃·Li
Molecular weight:520.63 6.94
Ref: 4Z-S-146002
5mg
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10mg
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25mg
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50mg
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100mg
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Siponimod
CAS:
- 1230487-00-9
Siponimod (BAF312) modulates S1P1/S1P5 with EC50s of 0.39/0.98 nM; >1000x selectivity over S1P2-4.
Formula:C₂₉H₃₅F₃N₂O₃
Purity:99.13% - 99.8%
Color and Shape:Solid
Molecular weight:516.59
Ref: TM-T6403
2mg
37.00€
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5mg
54.00€
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1mL*10mM (DMSO)
62.00€
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10mg
82.00€
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25mg
132.00€
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50mg
212.00€
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100mg
294.00€
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Siponimod
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 1230487-00-9
Applications Siponimod is a functional sphingosine -1 phosphate (SIP) antagonist used in the treatment of multiple sclerosis and other central nervous system-related diseases in human subjects. .
References Pelz, A., et al.: Eur. J. Immunol., 48, 498 (2018); O'Sullivan, S., et al.: Neuropharmacology, 113, 597 (2017)
Formula:C₂₉H₃₅F₃N₂O₃
Color and Shape:Neat
Molecular weight:516.6
Ref: TR-S683660
2500µg
112.00€
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25mg
388.00€
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Siponimod
CAS:
- 1230487-00-9
Sphingosine-1-phosphate receptor modulator
Formula:C₂₉H₃₅F₃N₂O₃
Purity:Min. 95%
Color and Shape:Powder
Molecular weight:516.6 g/mol
Ref: 3D-FS103613
25mg
286.00€
VAT not included
50mg
419.00€
VAT not included
100mg
615.00€
VAT not included
250mg
1,222.00€
VAT not included
500mg
2,260.00€
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SIPONIMOD
CAS:
- 1230487-00-9
Purity:99%
Molecular weight:516.6049805
Ref: 10-F799830
5mg
74.00€
VAT not included
25mg
212.00€
VAT not included
50mg
320.00€
VAT not included
100mg
479.00€
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250mg
799.00€
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Siponimod N-Oxide
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 1230487-00-9
Formula:C₂₉H₃₅F₃N₂O₄
Color and Shape:Neat
Molecular weight:532.6
Ref: TR-S374890
10mg
335.00€
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Siponimod-D11
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 1230487-00-9
Formula:C₂₉D₁₁H₂₄F₃N₂O₃
Color and Shape:Neat
Molecular weight:527.663
Ref: TR-S683662
25mg
46,837.00€
VAT not included
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Siponimod
CAS:
- 1230487-00-9
Formula:C₂₉H₃₅F₃N₂O₃
Molecular weight:516.61
Ref: ST-EA-CP-S29000
10mg
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25mg
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50mg
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100mg
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