CAS 123372-14-5

(R)-(+)-O-DESMETHYLCARVEDILOL

Description:

(R)-(+)-O-DESMETHYLCARVEDILOL is a chiral compound that belongs to the class of beta-blockers, specifically derived from carvedilol, which is used primarily in the treatment of hypertension and heart failure. This substance exhibits both beta-adrenergic blocking and alpha-1 adrenergic blocking properties, contributing to its effectiveness in managing cardiovascular conditions. The (R)-enantiomer is known for its higher potency compared to its (S)-counterpart, influencing its pharmacological activity. The compound is characterized by its ability to improve cardiac function and reduce blood pressure by inhibiting the effects of adrenaline on the heart and blood vessels. Additionally, it may possess antioxidant properties, which can further benefit cardiovascular health. As with many pharmaceutical compounds, the safety profile, potential side effects, and interactions with other medications are important considerations in its therapeutic use. Overall, (R)-(+)-O-DESMETHYLCARVEDILOL represents a significant compound in the realm of cardiovascular pharmacotherapy.

Formula: C₂₃H₂₄N₂O₄

InChI: InChI=1/C23H24N2O4/c26-16(14-24-12-13-28-21-10-4-3-9-20(21)27)15-29-22-11-5-8-19-23(22)17-6-1-2-7-18(17)25-19/h1-11,16,24-27H,12-15H2/t16-/m0/s1

InChI key: InChIKey=XAUKPPPYYOKVQJ-MRXNPFEDSA-N

SMILES: O(C[C@@H](CNCCOC1=C(O)C=CC=C1)O)C2=C3C=4C(NC3=CC=C2)=CC=CC4

Synonyms:

• (R)-(+)-Desmethyl Carvedilol
• (R)-2-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]phenol
• 2-[2-[[(2R)-3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]phenol
• Phenol, 2-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-, (R)-
• (R)-(+)-O-Desmethylcarvedilol

Phenol, 2-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-, (R)- (9CI)

CAS: 123372-14-5

Formula: C₂₃H₂₄N₂O₄

Color and Shape: Solid

Molecular weight: 392.4477

Ref: IN-DA000KHA

(R)-(+)-O-Desmethyl Carvedilol

CAS: 123372-14-5

Formula: C₂₃H₂₄N₂O₄

Molecular weight: 392.46

Ref: 4Z-C-0250

(R)-(+)-O-Desmethyl Carvedilol

Controlled Product

CAS: 123372-14-5

Applications An optically active metabolite of Carvedilol (C184625), a nonselective ß-adrenergic blocker with α-1-blocking activity. [α]D= +18.7 (c= 0.1 methanol)
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., et al.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Clohs, L., et al.: J. Pharm. Biomed. Anal., 31, 407 (2003),

Formula: C₂₃H₂₄N₂O₄

Color and Shape: Neat

Molecular weight: 392.45

Ref: TR-D291480