CAS 1240489-67-1

N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(3-pyridinyl)ethynyl]benzamide

Formula: C₂₉H₂₉F₃N₄O

InChI: InChI=1S/C29H29F3N4O/c1-3-35-13-15-36(16-14-35)20-25-10-11-26(18-27(25)29(30,31)32)34-28(37)24-8-6-21(2)23(17-24)9-7-22-5-4-12-33-19-22/h4-6,8,10-12,17-19H,3,13-16,20H2,1-2H3,(H,34,37)

InChI key: NIEOGXWKNYZXLD-UHFFFAOYSA-N

SMILES: CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)C#CC4=CN=CC=C4)C(F)(F)F

Synonyms:

• N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(3-pyridinyl)ethynyl]benzamide

XMD15-44

CAS: 1240489-67-1

XMD15-44, a RET kinase inhibitor, demonstrates potent growth-inhibitory effects on RAT1 cells transformed by RET/C634R and RET/M918T, with IC50 values of 11.5 nM and 8.3 nM, respectively. It effectively inhibits RET kinase activity and signaling in human thyroid cancer cell lines harboring oncogenic RET alleles, thereby reducing cell proliferation.

Formula: C₂₉H₂₉F₃N₄O

Color and Shape: Solid

Molecular weight: 506.56

Ref: TM-T200297