CAS 1243243-89-1

Wnt-C59 (C59)

Description:

Wnt-C59, also known by its CAS number 1243243-89-1, is a small molecule inhibitor that specifically targets the Wnt signaling pathway, which plays a crucial role in various biological processes, including cell proliferation, differentiation, and embryonic development. This compound is particularly noted for its ability to inhibit the activity of Porcupine, an enzyme involved in the palmitoylation of Wnt proteins, thereby preventing their secretion and subsequent signaling. Wnt-C59 has garnered interest in the field of cancer research, as aberrant Wnt signaling is often implicated in tumorigenesis. The compound is typically characterized by its moderate solubility in organic solvents and its stability under physiological conditions. In preclinical studies, Wnt-C59 has shown potential in reducing tumor growth in models of Wnt-dependent cancers, making it a candidate for further investigation in therapeutic applications. However, as with any investigational compound, its safety, efficacy, and pharmacokinetics require thorough evaluation through clinical trials before any potential clinical use.

Formula: C25H21N3O

InChI: InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29)

InChI key: KHZOJCQBHJUJFY-UHFFFAOYSA-N

SMILES: CC1=NC=CC(=C1)C2=CC=C(C=C2)CC(=O)NC3=CC=C(C=C3)C4=CN=CC=C4

Synonyms:

• Wnt-C59
• WNT C59
• 4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide
• 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetaMide

Benzeneacetamide, 4-(2-methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]-

CAS: 1243243-89-1

Formula: C₂₅H₂₁N₃O

Purity: 98%

Color and Shape: Solid

Molecular weight: 379.4537

Ref: IN-DA000LUB

2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide

CAS: 1243243-89-1

2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide

Formula: C₂₅H₂₁N₃O

Purity: ≥98%

Molecular weight: 379.45374

Ref: 54-OR302635

Wnt-C59

CAS: 1243243-89-1

Wnt-C59

Formula: C₂₅H₂₁N₃O

Purity: ≥98%

Molecular weight: 379.45

Ref: 54-BUP09764

Wnt-C59

Controlled Product

CAS: 1243243-89-1

Applications Wnt-C59 is a porcupine homolog – Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase.
References Proffitt, K., et al.: Cancer Res., 73, 502 (2013); Wend, P., et al.: EMBO Mol. Med., 5, 264 (2013); Petrova, E., et al.: Nat. Chem. Biol., 9, 247 (2013); Youssef, K., et al.: Nat. Cell. Biol., 14, 1282 (2012)

Formula: C₈H₁₁N₅O₃

Color and Shape: Neat

Molecular weight: 225.205

Ref: TR-W499300

Wnt-C59

CAS: 1243243-89-1

Formula: C₂₅H₂₁N₃O

Molecular weight: 379.46

Ref: 4Z-K-031046

Wnt-C59

CAS: 1243243-89-1

Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.

Formula: C₂₅H₂₁N₃O

Purity: 99.56% - 99.97%

Color and Shape: Solid

Molecular weight: 379.45

Ref: TM-T2242

Wnt-C59

CAS: 1243243-89-1

Formula: C₂₅H₂₁N₃O

Molecular weight: 379.5

Ref: BE-RMCK020046

Wnt-C59

CAS: 1243243-89-1

2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide

Formula: C₂₅H₂₁N₃O

Purity: 98%

Molecular weight: 379.45

Ref: IN-DG289734

2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide

CAS: 1243243-89-1

Formula: C₂₅H₂₁N₃O

Purity: 98%

Color and Shape: Solid

Molecular weight: 379.463

Ref: 10-F462203

Wnt-C59

CAS: 1243243-89-1

Inhibitor of PORCN O-acyltransferase; inhibitor of WNT

Formula: C₂₅H₂₁N₃O

Purity: Area-% Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 379.45 g/mol

Ref: 3D-FM161562