CAS 1243244-14-5

LGK974

Description:

LGK974, also known by its chemical name, is a small molecule inhibitor that specifically targets the enzyme porcupine, which is involved in the Wnt signaling pathway. This pathway plays a crucial role in various biological processes, including cell proliferation, differentiation, and stem cell maintenance. By inhibiting porcupine, LGK974 effectively reduces the secretion of Wnt ligands, thereby modulating Wnt signaling. This characteristic makes it a potential therapeutic agent in the treatment of various cancers and other diseases associated with aberrant Wnt signaling. LGK974 has been studied in preclinical models for its efficacy and safety profile, showing promise in inhibiting tumor growth. Additionally, its pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, are critical for determining its suitability for clinical use. As research continues, LGK974 may contribute to the development of targeted therapies aimed at conditions where Wnt signaling is dysregulated.

[2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-

CAS: 1243244-14-5

Formula: C₂₃H₂₀N₆O

Purity: 99%

Color and Shape: Solid

Molecular weight: 396.4445

Ref: IN-DA000LUA

LGK974

CAS: 1243244-14-5

LGK974

Purity: ≥98%

Molecular weight: 396.44g/mol

Ref: 54-BUP07851

2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide

CAS: 1243244-14-5

2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide

Purity: 98%

Molecular weight: 396.44g/mol

Ref: 54-OR302651

LGK974

CAS: 1243244-14-5

LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.

Formula: C₂₃H₂₀N₆O

Purity: 98.8% - >99.99%

Color and Shape: Solid

Molecular weight: 396.44

Ref: TM-T2618

2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide

CAS: 1243244-14-5

Purity: 95.0%

Molecular weight: 396.4540100097656

Ref: 10-F465541

LGK 974

CAS: 1243244-14-5

Inhibits Wnt signaling pathway by targeting porcupine, a membrane-bound O-acyltransferase involved in the palmitoylation and secretion of Wnt. Anti-cancer properties of LGK 974 have been demonstrated in various tumor models of breast cancer, head and neck squamous cell carcinoma and glioblastoma. Blocks LPS-mediated inflammatory response in epithelial and endothelial cells.

Formula: C₂₃H₂₀N₆O

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 396.40 g/mol

Ref: 3D-FL76327

LGK 974

Controlled Product

CAS: 1243244-14-5

Applications LGK 974 is a potent and specific small molecule Porcupine (PORCN) inhibitor.
References Liu, J., et. al.: Roc. Natl. Acad. Sci. USA, 110, 20224 (2013)

Formula: C₂₃H₂₀N₆O

Color and Shape: Neat

Molecular weight: 396.44

Ref: TR-L397640