CAS 1246817-85-5

Nilotinib N-Oxide

Description:

Nilotinib N-Oxide is a chemical compound derived from nilotinib, which is primarily used as a targeted therapy for chronic myeloid leukemia (CML). As a derivative, N-Oxide indicates the presence of an oxidized nitrogen atom in its structure. This modification can influence the compound's pharmacological properties, including its solubility, stability, and bioavailability. Typically, N-oxides exhibit enhanced polar characteristics compared to their parent compounds, which may affect their interaction with biological systems. The compound is expected to have a specific molecular weight and structural formula that reflects its unique arrangement of atoms. In terms of safety and handling, like many pharmaceutical compounds, nilotinib N-Oxide should be managed with care, adhering to appropriate safety protocols to mitigate any potential risks associated with exposure. Its efficacy and safety profile would be evaluated through rigorous clinical studies, similar to other pharmaceutical agents, to determine its therapeutic potential and any side effects.

Formula: C₂₈H₂₂F₃N₇O₂

Synonyms:

• 4-Methyl-N-[3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)phenyl]-3-[[4-(3-pyridinyl-N-oxide)-2-pyriMidinyl]aMino]benzaMide
• Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(1-oxido-3-pyridinyl)-2-pyrimidinyl]amino]-
• Nilotinib N-Oxide
• NILOTINIB?N-OXIDE (PYRIDINE?N-OXIDE)
• Nilotinib N-Oxide Impurity 2
• 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(1-oxidopyridin-1-ium-3-yl)pyrimidin-2-yl]amino]benzamide

Nilotinib N-Oxide (Pyridine N-Oxide)

CAS: 1246817-85-5

Formula: C₂₈H₂₂F₃N₇O₂

Color and Shape: Yellow Solid

Molecular weight: 545.53

Ref: 4Z-N-313

Nilotinib N-Oxide

Controlled Product

CAS: 1246817-85-5

Applications A metabolite of Nilotinib (N465300). It is a COVID19-related research product.

Formula: C₂₈H₂₂F₃N₇O₂

Color and Shape: Neat

Molecular weight: 545.52

Ref: TR-N465310

Nilotinib N-oxide

CAS: 1246817-85-5

Nilotinib N-oxide is a bosutinib metabolite that is categorized as a profile 1B inhibitor. It has a chemical structure similar to imatinib and dasatinib. The metabolite of nilotinib N-oxide, which is an active form, focuses on the inhibition of chronic myeloid leukemia (CML) cells by targeting the oncoprotein BCR-ABL. Nilotinib N-oxide has been shown to have cardiac toxicity, which may be due to its ability to inhibit the synthesis of uridine and reduce thrombocytopenia. It also has the potential for toxicities such as pancreatitis and hepatotoxicity.

Formula: C₂₈H₂₂F₃N₇O₂

Purity: Min. 95%

Molecular weight: 545.5 g/mol

Ref: 3D-WZB81785

Nilotinib pyridine N-Oxide

CAS: 1246817-85-5

Formula: C₂₈H₂₂F₃N₇O₂

Molecular weight: 545.53

Ref: ST-EA-CP-N11012

Nilotinib N-oxide

CAS: 1246817-85-5

Nilotinib N-oxide is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia.

Formula: C₂₈H₂₂F₃N₇O₂

Color and Shape: Solid

Molecular weight: 545.52

Ref: TM-T71144