CAS 124904-93-4

ganirelix

Description:

Ganirelix is a synthetic peptide that functions as a gonadotropin-releasing hormone (GnRH) antagonist. It is primarily used in assisted reproductive technology to prevent premature ovulation during controlled ovarian stimulation. The substance is characterized by its ability to competitively inhibit the action of GnRH at the pituitary gland, thereby reducing the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This mechanism helps to control the timing of ovulation, allowing for better management of fertility treatments. Ganirelix is typically administered via subcutaneous injection and is known for its relatively short half-life, necessitating careful timing in relation to the ovarian stimulation protocol. The compound is generally well-tolerated, with side effects that may include injection site reactions, headache, and nausea. Its chemical structure consists of a sequence of amino acids, contributing to its biological activity and specificity in targeting GnRH receptors. Ganirelix is an important tool in reproductive medicine, aiding in the optimization of fertility outcomes.

Formula: C₈₀H₁₁₃ClN₁₈O₁₃

InChI: InChI=1/C80H113ClN18O13/c1-9-84-79(85-10-2)88-39-17-15-27-60(70(104)94-62(42-49(5)6)71(105)93-61(28-16-18-40-89-80(86-11-3)87-12-4)78(112)99-41-21-29-68(99)77(111)90-50(7)69(82)103)92-72(106)63(44-53-32-36-58(102)37-33-53)97-76(110)67(48-100)98-74(108)65(45-54-22-20-38-83-47-54)96-73(107)64(43-52-30-34-57(81)35-31-52)95-75(109)66(91-51(8)101)46-56-25-19-24-55-23-13-14-26-59(55)56/h13-14,19-20,22-26,30-38,47,49-50,60-68,100,102H,9-12,15-18,21,27-29,39-46,48H2,1-8H3,(H2,82,103)(H,90,111)(H,91,101)(H,92,106)(H,93,105)(H,94,104)(H,95,109)(H,96,107)(H,97,110)(H,98,108)(H2,84,85,88)(H2,86,87,89)/t50-,60-,61+,62+,63+,64-,65-,66-,67+,68+/m1/s1

Synonyms:

• N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylamino)methylene]-D-lysyl-L-leucyl-N6-[bis(ethylamino)methylene]-L-lysyl-L-prolyl-D-alaninamide
• Orgalutran
• Rs 26306

(2R)-N-[(1S)-1-{[(2S)-1-[(2S)-2-{[(1R)-1-carbamoylethyl]carbamoyl}pyrrolidin-1-yl]-6-(N',N''-diethylcarbamimidamido)-1-oxohexan-2-yl]carbamoyl}-3-methylbutyl]-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2R)-3-(4-chlorophenyl)-2-[(2R)-2-acetamido-3-(naphthalen-2-yl)propanamido]propanamido]-3-(pyridin-3-yl)propanamido]-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-6-(N',N''-diethylcarbamimidamido)hexanamide

CAS: 124904-93-4

Formula: C₈₀H₁₁₃ClN₁₈O₁₃

Molecular weight: 1570.3190

Ref: IN-DA000MVZ

Ganirelix

CAS: 124904-93-4

Formula: C₈₀H₁₁₃ClN₁₈O₁₃

Molecular weight: 1570.36

Ref: 4Z-PG-046001

Ganirelix Trifluoroacetic Acid Salt (>90%)

Controlled Product

CAS: 124904-93-4, 129311-55-3

Applications Decapeptide LH-RH antagonist. Used in treatment of infertility.
References Strickley, R.G., et al.: Pharm. Res., 7, 530 (1990), Jung, G., et al.: J. Med. Chem., 35, 3942 (1992), Rabinovici, J., et al.: J. Clin. Endocrinol. Metab., 75, 1220 (1992), Devroey, P., et al.: Hum. Reprod., 13, 3023 (1998),

Formula: C₈₀H₁₁₃ClN₁₈O₁₃•x(C₂HF₃O₂)

Purity: >90%

Color and Shape: Neat

Molecular weight: 1570.3211402

Ref: TR-G245000

Ganirelix Impurity D (Monoacetyl Ganirelix)

Controlled Product

CAS: 124904-93-4

Applications Ganirelix Impurity D (Monoacetyl Ganirelix), is an impurity of Ganirelix (G245000), a decapeptide LH-RH antagonist. Used in treatment of infertility.

Formula: C₈₂H₁₁₅ClN₁₈O₁₄

Color and Shape: Neat

Molecular weight: 1612.38

Ref: TR-G244990