CAS 124904-93-4
:ganirelix
Description:
Ganirelix is a synthetic peptide that functions as a gonadotropin-releasing hormone (GnRH) antagonist. It is primarily used in assisted reproductive technology to prevent premature ovulation during controlled ovarian stimulation. The substance is characterized by its ability to competitively inhibit the action of GnRH at the pituitary gland, thereby reducing the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This mechanism helps to control the timing of ovulation, allowing for better management of fertility treatments. Ganirelix is typically administered via subcutaneous injection and is known for its relatively short half-life, necessitating careful timing in relation to the ovarian stimulation protocol. The compound is generally well-tolerated, with side effects that may include injection site reactions, headache, and nausea. Its chemical structure consists of a sequence of amino acids, contributing to its biological activity and specificity in targeting GnRH receptors. Ganirelix is an important tool in reproductive medicine, aiding in the optimization of fertility outcomes.
Formula:C80H113ClN18O13
InChI:InChI=1/C80H113ClN18O13/c1-9-84-79(85-10-2)88-39-17-15-27-60(70(104)94-62(42-49(5)6)71(105)93-61(28-16-18-40-89-80(86-11-3)87-12-4)78(112)99-41-21-29-68(99)77(111)90-50(7)69(82)103)92-72(106)63(44-53-32-36-58(102)37-33-53)97-76(110)67(48-100)98-74(108)65(45-54-22-20-38-83-47-54)96-73(107)64(43-52-30-34-57(81)35-31-52)95-75(109)66(91-51(8)101)46-56-25-19-24-55-23-13-14-26-59(55)56/h13-14,19-20,22-26,30-38,47,49-50,60-68,100,102H,9-12,15-18,21,27-29,39-46,48H2,1-8H3,(H2,82,103)(H,90,111)(H,91,101)(H,92,106)(H,93,105)(H,94,104)(H,95,109)(H,96,107)(H,97,110)(H,98,108)(H2,84,85,88)(H2,86,87,89)/t50-,60-,61+,62+,63+,64-,65-,66-,67+,68+/m1/s1
InChI key:GJNXBNATEDXMAK-PFLSVRRQSA-N
SMILES:CCNC(=NCCCC[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN=C(NCC)NCC)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)N)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC3=CN=CC=C3)NC(=O)[C@@H](CC4=CC=C(C=C4)Cl)NC(=O)[C@@H](CC5=CC6=CC=CC=C6C=C5)NC(=O)C)NCC
Synonyms:- N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylamino)methylene]-D-lysyl-L-leucyl-N6-[bis(ethylamino)methylene]-L-lysyl-L-prolyl-D-alaninamide
- Orgalutran
- Rs 26306
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Ganirelix
CAS:Ganirelix is a GnRH antagonist that inhibits LH and FSH release.Formula:C82H117ClN18O15Molecular weight:1630.371Ganirelix Trifluoroacetic Acid Salt (>90%)
CAS:Controlled ProductApplications Decapeptide LH-RH antagonist. Used in treatment of infertility.
References Strickley, R.G., et al.: Pharm. Res., 7, 530 (1990), Jung, G., et al.: J. Med. Chem., 35, 3942 (1992), Rabinovici, J., et al.: J. Clin. Endocrinol. Metab., 75, 1220 (1992), Devroey, P., et al.: Hum. Reprod., 13, 3023 (1998),Formula:C80H113ClN18O13•x(C2HF3O2)Purity:>90%Color and Shape:NeatMolecular weight:1570.32114Ganirelix Impurity D (Monoacetyl Ganirelix)
CAS:Controlled ProductApplications Ganirelix Impurity D (Monoacetyl Ganirelix), is an impurity of Ganirelix (G245000), a decapeptide LH-RH antagonist. Used in treatment of infertility.
Formula:C82H115ClN18O14Color and Shape:NeatMolecular weight:1612.38(2R)-N-[(1S)-1-{[(2S)-1-[(2S)-2-{[(1R)-1-carbamoylethyl]carbamoyl}pyrrolidin-1-yl]-6-(N',N''-diethylcarbamimidamido)-1-oxohexan-2-yl]carbamoyl}-3-methylbutyl]-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2R)-3-(4-chlorophenyl)-2-[(2R)-2-acetamido-3-(naphthalen-2-yl)propanamido]propanamido]-3-(pyridin-3-yl)propanamido]-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-6-(N',N''-diethylcarbamimidamido)hexanamide
CAS:Formula:C80H113ClN18O13Molecular weight:1570.3190
![(2R)-N-[(1S)-1-{[(2S)-1-[(2S)-2-{[(1R)-1-carbamoylethyl]carbamoyl}pyrrolidin-1-yl]-6-(N',N''-dieth…](https://static.cymitquimica.com/products/IN/thumb/DA000MVZ.jpg)
