CAS 1253056-01-7

Sitagliptin Alcohol (3-hydroxy-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one)

CAS: 1253056-01-7

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Formula: C₁₆H₁₄F₆N₄O₂

Color and Shape: Off-White Solid

Molecular weight: 408.10209

Ref: 45-1A02660

Sitagliptin Impurity 13

CAS: 1253056-01-7

Formula: C₁₆H₁₄F₆N₄O₂

Color and Shape: White To Off-White Solid

Molecular weight: 408.30

Ref: 4Z-S-2056

1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-hydroxy-4-(2,4,5-trifluorophenyl)-1-butanone

Controlled Product

CAS: 1253056-01-7

Applications 1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-hydroxy-4-(2,4,5-trifluorophenyl)-1-butanone is an intermediate in the synthesis of 3-Desamino-2,3-dehydro Sitagliptin (D281985), which is an impurity of Sitagliptin (S491000); a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.
References Kim, D., et al.: J. Med. Chem. 48, 141 (2005); Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005); Bergman, A., et al: Clin. Ther. 28, 55 (2006)

Formula: C₁₆H₁₄F₆N₄O₂

Color and Shape: White To Off-White

Molecular weight: 408.3

Ref: TR-D461960

Sitagliptin hydroxy amide impurity

CAS: 1253056-01-7

Sitagliptin is an oral dipeptidyl peptidase-4 inhibitor that is used to treat type 2 diabetes. It binds to the active site of the enzyme and reversibly blocks the action of the enzyme, thereby inhibiting the breakdown of a number of important hormones such as glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide. Sitagliptin hydroxy amide impurity is an impurity in sitagliptin that inhibits oxidoreductases, enzymes that catalyze oxidation reactions. The enantiomeric purity of sitagliptin hydroxy amide impurity is unknown.

Formula: C₁₆H₁₄F₆N₄O₂

Purity: Min. 95%

Molecular weight: 408.3 g/mol

Ref: 3D-IS106472

3-Hydroxy Sitagliptin

CAS: 1253056-01-7

Formula: C₁₆H₁₄F₆N₄O₂

Molecular weight: 408.30

Ref: ST-EA-CP-S3050