CAS 125441-00-1

N-acetyl-(tyr(so3H)63)-hirudin *fragment 54-65

Description:

N-acetyl-(tyr(so3H)63)-hirudin *fragment 54-65 is a synthetic peptide derived from hirudin, a naturally occurring anticoagulant protein found in leeches. This specific fragment consists of amino acids 54 to 65 of the hirudin sequence, modified with an N-acetyl group and a sulfated tyrosine residue (tyr(so3H)63). The presence of the N-acetyl group enhances its stability and bioavailability, while the sulfation of the tyrosine residue can influence its interaction with biological targets, particularly in the context of anticoagulation. Hirudin and its derivatives are known for their potent inhibitory effects on thrombin, making them of significant interest in therapeutic applications related to blood coagulation disorders. The molecular structure of this fragment includes a sequence of amino acids that contribute to its biological activity, and its specific modifications can affect its pharmacokinetics and pharmacodynamics. Overall, this compound represents a valuable tool in the study of anticoagulant mechanisms and potential therapeutic interventions.

Formula: C₆₈H₉₅N₁₃O₂₉S

Synonyms:

• Acetyl-Hirudin (54-65) (sulfated)
• Ac-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr(SO3H)-Leu-Gln-OH

Acetyl-Hirudin (54-65) (sulfated)

CAS: 125441-00-1

Acetyl-Hirudin (54-65) (sulfated) binds thrombin-rHCII(L444R), blocking rHCII's N-terminal/thrombin exosite I interaction, stabilizing the complex.

Formula: C₆₈H₉₅N₁₃O₂₉S

Color and Shape: Solid

Molecular weight: 1590.63

Ref: TM-T38645

Acetyl-Hirudin (54-65) (sulfated)

CAS: 125441-00-1

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Formula: C₆₈H₉₅N₁₃O₂₉S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,590.62 g/mol

Ref: 3D-FA110094