CAS 1255700-88-9

Formula: C25H26N6O2

InChI: InChI=1S/C25H26N6O2/c1-30-14-18-9-11-22(28-24(18)33-21(16-30)17-7-5-4-6-8-17)27-23-12-10-20(25(29-23)32-3)19-13-26-31(2)15-19/h4-13,15,21H,14,16H2,1-3H3,(H,27,28,29)/t21-/m0/s1

InChI key: IKUXSEKKQNIOCQ-NRFANRHFSA-N

SMILES: CN1C[C@H](OC2=C(C1)C=CC(=N2)NC3=NC(=C(C=C3)C4=CN(N=C4)C)OC)C5=CC=CC=C5

γ-secretase modulator 6

CAS: 1255700-88-9

Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.

Formula: C₂₅H₂₆N₆O₂

Color and Shape: Solid

Molecular weight: 442.513

Ref: TM-T206107