CAS 1256580-46-7

Alectinib

Description:

Alectinib is a small molecule drug primarily used in the treatment of non-small cell lung cancer (NSCLC) that is positive for anaplastic lymphoma kinase (ALK) gene rearrangements. It functions as a selective inhibitor of ALK, disrupting the signaling pathways that promote tumor growth and survival. Alectinib is characterized by its high potency and specificity for ALK, which helps minimize off-target effects and enhances its therapeutic efficacy. The compound is typically administered orally and has a favorable pharmacokinetic profile, including good absorption and a long half-life, allowing for once or twice daily dosing. Its chemical structure includes a bicyclic core, contributing to its ability to penetrate the blood-brain barrier, making it effective against brain metastases associated with ALK-positive NSCLC. Common side effects may include fatigue, constipation, and liver enzyme elevations, necessitating monitoring during treatment. Overall, Alectinib represents a significant advancement in targeted cancer therapy, offering improved outcomes for patients with specific genetic profiles.

Formula: C₃₀H₃₄N₄O₂

InChI: InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3

InChI key: InChIKey=KDGFLJKFZUIJMX-UHFFFAOYSA-N

SMILES: O=C1C2=C(C(C)(C)C=3C1=CC(CC)=C(C3)N4CCC(CC4)N5CCOCC5)NC=6C2=CC=C(C#N)C6

Synonyms:

• 5H-Benzo[b]carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-
• 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
• Af 802
• Alecensa free base
• Ch 5424802
• Ch 542480210
• Rg 7853
• Rg7853
• Alectinib
• Alectinib (CH5424802)
• AF-802,RG-7853
• CH5424802
• CH5424802-alectinib
• 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Alectinib (CH5424802)

9-Ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile

CAS: 1256580-46-7

Formula: C₃₀H₃₄N₄O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 482.6166

Ref: IN-DA000O9H

Alectinib

CAS: 1256580-46-7

Formula: C₃₀H₃₄N₄O₂

Color and Shape: Off-White Solid

Molecular weight: 482.63

Ref: 4Z-A-239001

Alectinib

CAS: 1256580-46-7

Alectinib

Purity: ≥98%

Molecular weight: 482.62g/mol

Ref: 54-BUP14479

Alectinib-d8

CAS: 1256580-46-7

Formula: C₃₀H₂₆D₈N₄O₂

Molecular weight: 490.68

Ref: 4Z-A-239006

Alectinib-d5

CAS: 1256580-46-7

Formula: C₃₀H₂₉D₅N₄O₂

Molecular weight: 487.66

Ref: 4Z-A-239005

Alectinib

CAS: 1256580-46-7

Alectinib (RG-7853) is an ALK inhibitor that is selective, orally active, and ATP-competitive. Alectinib has antitumor activity. Cost-effective and quality-assured.

Formula: C₃₀H₃₄N₄O₂

Purity: 98% - 99.38%

Color and Shape: Solid

Molecular weight: 482.62

Ref: TM-T1936

Alectinib

CAS: 1256580-46-7

Alectinib

Purity: 98%

Molecular weight: 482.62g/mol

Ref: 54-BISN0151

CH5424802

Controlled Product

CAS: 1256580-46-7

Applications CH5424802 is a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth. CH5424802 have been clinically evaluated for the treatment of patients with ALK-driven tumors. Potent ALK inhibitor
References Sakamoto, H., et al.: Cancer Cell., 19, 679 (2011); Kinoshita, K., et al.: Bio-org. Medn., 20, 1271 (2012);

Formula: C₃₀H₃₄N₄O₂

Color and Shape: Neat

Molecular weight: 482.62

Ref: TR-C183360

Alectinib

CAS: 1256580-46-7

Alectinib is a drug that inhibits the activity of tyrosine kinases, including ALK, ROS1, and MET. It binds to ATP-binding sites in the active site of these enzymes and prevents them from transferring phosphate groups onto their substrates. Alectinib also inhibits the activity of polymerase chain reaction (PCR) in vitro by binding to DNA. This drug has been shown to inhibit the growth of lymphoma cells in mice by inhibiting protein synthesis and inducing apoptosis. Alectinib also acts as a p-glycoprotein (Pgp) inhibitor, which may be due to its ability to inhibit an alkaline phosphatase.

Formula: C₃₀H₃₄N₄O₂

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 482.62 g/mol

Ref: 3D-FA75280

CH5424802-d8

Controlled Product

CAS: 1256580-46-7

Applications CH5424802-d8 is the labelled form of CH5424802 (C183360). CH5424802 is a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth. CH5424802 have been clinically evaluated for the treatment of patients with ALK-driven tumors.
References Sakamoto, H., et al.: Cancer Cell., 19, 679 (2011); Kinoshita, K., et al.: Bio-org. Medn., 20, 1271 (2012)

Formula: C₃₀H₂₆D₈N₄O₂

Color and Shape: Neat

Molecular weight: 490.67

Ref: TR-C183362