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Alectinib

CAS 1256580-46-7: Alectinib

Description:Alectinib is a small molecule drug primarily used in the treatment of non-small cell lung cancer (NSCLC) that is positive for anaplastic lymphoma kinase (ALK) gene rearrangements. It functions as a selective inhibitor of ALK, disrupting the signaling pathways that promote tumor growth and survival. Alectinib is characterized by its high potency and specificity for ALK, which helps minimize off-target effects and enhances its therapeutic efficacy. The compound is typically administered orally and has a favorable pharmacokinetic profile, including good absorption and a long half-life, allowing for once or twice daily dosing. Its chemical structure includes a bicyclic core, contributing to its ability to penetrate the blood-brain barrier, making it effective against brain metastases associated with ALK-positive NSCLC. Common side effects may include fatigue, constipation, and liver enzyme elevations, necessitating monitoring during treatment. Overall, Alectinib represents a significant advancement in targeted cancer therapy, offering improved outcomes for patients with specific genetic profiles.

Formula:C30H34N4O2

InChI:InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3

InChI key:InChIKey=KDGFLJKFZUIJMX-UHFFFAOYSA-N

SMILES:N#CC=1C=CC2=C(C1)NC3=C2C(=O)C=4C=C(C(=CC4C3(C)C)N5CCC(N6CCOCC6)CC5)CC

  • Synonyms:
  • 5H-Benzo[b]carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-
  • 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
  • Af 802
  • Alecensa free base
  • Ch 5424802
  • Ch 542480210
  • Rg 7853
  • Rg7853
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Ref: IN-DA000O9H

1g106.00 €
5g337.00 €
10g477.00 €
100mg46.00 €
250mg49.00 €
Estimated delivery in United States, on Tuesday 4 Mar 2025
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Alectinib

CAS:1256580-46-7

Ref: 4Z-A-239001

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Estimated delivery in United States, on Wednesday 5 Mar 2025
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Ref: 4Z-A-239006

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Estimated delivery in United States, on Tuesday 11 Mar 2025
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Ref: 4Z-A-239005

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Estimated delivery in United States, on Tuesday 11 Mar 2025
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Alectinib

CAS:1256580-46-7

Ref: 54-BISN0151

1g222.00 €
5g719.00 €
100mg45.00 €
250mg71.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
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Alectinib

CAS:1256580-46-7

Ref: TM-T1936

2mg47.00 €
5mg69.00 €
10mg87.00 €
50mg105.00 €
100mg168.00 €
200mg259.00 €
500mg437.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
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Alectinib

CAS:1256580-46-7

Ref: 3D-FA75280

1g651.00 €
2g886.00 €
5g1,417.00 €
250mg278.00 €
500mg418.00 €
Estimated delivery in United States, on Monday 17 Mar 2025
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CH5424802

Controlled Product
CAS:1256580-46-7

Ref: TR-C183360

10mg208.00 €
25mg367.00 €
250mg1,748.00 €
Estimated delivery in United States, on Monday 14 Apr 2025
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CH5424802-d8

Controlled Product
CAS:1256580-46-7

Ref: TR-C183362

10mg2,353.00 €
Estimated delivery in United States, on Monday 14 Apr 2025
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