CAS 1258392-53-8

AZD-5582

Description:

AZD-5582 is a small molecule inhibitor primarily developed for its potential therapeutic applications in cancer treatment. It functions as a potent antagonist of the MDM2 protein, which is known for its role in regulating the p53 tumor suppressor pathway. By inhibiting MDM2, AZD-5582 aims to restore p53 activity, leading to increased apoptosis in cancer cells. The compound has been studied for its efficacy in various malignancies, particularly those with p53 mutations or dysregulation. AZD-5582 is characterized by its specific binding affinity to MDM2, which is crucial for its mechanism of action. Additionally, it has been evaluated in preclinical and clinical settings for its pharmacokinetic properties, safety profile, and potential to enhance the effectiveness of other anticancer therapies. As a research compound, AZD-5582 represents a promising avenue in targeted cancer therapy, particularly in the context of personalized medicine approaches that leverage the status of the p53 pathway in tumors.

Formula: C58H78N8O8

InChI: InChI=1S/C58H78N8O8/c1-37(59-3)53(67)61-49(39-21-9-7-10-22-39)57(71)65-31-19-29-45(65)55(69)63-51-43-27-15-13-25-41(43)35-47(51)73-33-17-5-6-18-34-74-48-36-42-26-14-16-28-44(42)52(48)64-56(70)46-30-20-32-66(46)58(72)50(40-23-11-8-12-24-40)62-54(68)38(2)60-4/h13-16,25-28,37-40,45-52,59-60H,7-12,19-24,29-36H2,1-4H3,(H,61,67)(H,62,68)(H,63,69)(H,64,70)/t37-,38-,45-,46-,47+,48+,49-,50-,51-,52-/m0/s1

InChI key: WLMCRYCCYXHPQF-ZVMUOSSASA-N

SMILES: C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C(=O)N[C@@H]3[C@@H](CC4=CC=CC=C34)OCC#CC#CCO[C@@H]5CC6=CC=CC=C6[C@@H]5NC(=O)[C@@H]7CCCN7C(=O)[C@H](C8CCCCC8)NC(=O)[C@H](C)NC)NC

(2S,2'S)-1,1'-((S,2S,2'S)-2,2'-(((1S,1'S,2R,2'R)-(Hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(cyclohexane-3,1-diyl))bis(2-((S)-2-(methylamino)propanamido)acetyl))bis(pyrrol

CAS: 1258392-53-8

(2S,2'S)-1,1'-((S,2S,2'S)-2,2'-(((1S,1'S,2R,2'R)-(Hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(cyclohexane-3,1-diyl))bis(2-((S)-2-(methylamino)propanamido)acetyl))bis(pyrrol

Formula: C₅₈H₇₈N₈O₈

Purity: 98%

Molecular weight: 1015.31

Ref: 54-OR1063134

AZD5582

CAS: 1258392-53-8

AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.

Formula: C₆₀H₇₉F₃N₈O₁₀

Purity: 98.75% - >99.99%

Color and Shape: Solid

Molecular weight: 1129.3121

Ref: TM-T14378

(2S,2'S)-1,1'-((S,2S,2'S)-2,2'-(((1S,1'S,2R,2'R)-(Hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(cyclohexane-3,1-diyl))bis(2-((S)-2-(methylamino)propanamido)acetyl))bis(pyrrolidine-2-carboxamide)

CAS: 1258392-53-8

Formula: C₅₈H₇₈N₈O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 1015.2887

Ref: IN-DA009CGX

AZD5582

CAS: 1258392-53-8

(2S,2'S)-1,1'-((S,2S,2'S)-2,2'-(((1S,1'S,2R,2'R)-(Hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(cyclohexane-3,1-diyl))bis(2-((S)-2-(methylamino)propanamido)acetyl))bis(pyrrolidine-2-carboxamide)

Formula: C₅₈H₇₈N₈O₈

Purity: 98%

Molecular weight: 1015.28

Ref: IN-DG630065

AZD 5582

CAS: 1258392-53-8

AZD 5582 is a small molecule that inhibits the protein MCL-1, which is a key regulator of apoptosis. Inhibiting MCL-1 leads to increased levels of the apoptosis protein BAX and decreased levels of the apoptosis inhibitor Bcl-2. This leads to cell death via caspase-independent pathways, such as mitochondrial dysfunction or necrosis. AZD 5582 has also been shown to have anti-inflammatory effects in autoimmune diseases, such as psoriasis and rheumatoid arthritis. The drug has been shown to be effective against solid tumours in animal models.

Formula: C₅₈H₇₈N₈O₈

Purity: Min. 95%

Molecular weight: 1,015.29 g/mol

Ref: 3D-IAC39253