CAS 126-07-8: Griseofulvin

Description: Griseofulvin is an antifungal medication primarily used to treat dermatophyte infections, particularly those affecting the skin, hair, and nails. It is derived from the mold Penicillium griseofulvum and functions by inhibiting fungal cell mitosis, thereby preventing the growth and reproduction of fungi. Griseofulvin is characterized by its crystalline structure and is typically administered orally. It is poorly soluble in water but more soluble in organic solvents, which influences its absorption and bioavailability. The substance is known for its relatively long half-life, allowing for once-daily dosing in many cases. Common side effects may include gastrointestinal disturbances, headache, and potential allergic reactions. Griseofulvin is contraindicated in certain populations, such as pregnant individuals, due to potential teratogenic effects. Its effectiveness is often assessed through clinical evaluation and laboratory tests to confirm the presence of susceptible fungal species. Overall, Griseofulvin remains a significant therapeutic option in the management of specific fungal infections.

Formula: C₁₇H₁₇ClO₆

InChI: InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1

InChI key: InChIKey=DDUHZTYCFQRHIY-RBHXEPJQSA-N

SMILES: O=C1C=C(OC)C2(OC=3C(Cl)=C(OC)C=C(OC)C3C2=O)C(C)C1

Synonyms:

• (1′S,6′R)-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione
• (2R,6'S)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
• (2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
• (2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohexane]-3,4'-dione
• (2S,6'S)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
• 7-Chloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione
• 7-Chloro-2',4,6-trimethoxy-6'β-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione
• 7-Chloro-2′,4,6-trimethoxy-6′β-methylspiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione
• 7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
• Amudane
• Curling factor
• Fulcin
• Fulvicin
• Fulvicin Bolus
• Fulvicin P/G
• Fulvicin U/F
• Fulvidex
• Fulvina
• Fulvinil
• Fulvistatin
• Gricin
• Grifulin
• Grifulvin
• Grifulvin V
• Gris-PEG
• Grisactin
• Grisefulin
• Griseofulvin Powder
• Griseofulvina
• Griseofulvine
• Griseovin
• Grisofulvin
• Grisovin
• Grisovin FP
• Grysio
• Idifulvin
• Lamoryl
• Likuden
• Neo-Fulcin
• Polygris
• Poncyl
• Poncyl FP
• Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S,6'R)-
• Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S-trans)-
• Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'β-methyl-
• Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione,7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'R-trans)-
• Spiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione, 7-chloro-2′,4,6-trimethoxy-6′-methyl-, (1′S,6′R)-
• Spiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione, 7-chloro-2′,4,6-trimethoxy-6′-methyl-, (1′S-trans)-
• Spiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione, 7-chloro-2′,4,6-trimethoxy-6′β-methyl-
• Spirofulvin
• Sporostatin
• Xuanjing
• (+)-Griseofulvin

Griseofulvin

CAS: 126-07-8

Anti-fungal; microtubule polymerization inhibitor

• Formula: C₁₇H₁₇ClO₆
• Purity: Min. 97 Area-%
• Color and Shape: Powder
• Molecular weight: 352.77 g/mol

Griseofulvin

CAS: 126-07-8

• Formula: C₁₇H₁₇ClO₆
• Purity: 99.8% / 98.3%
• Color and Shape: White
• Molecular weight: 352.07137