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CAS 1260075-17-9

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Mitapivat

Description:
Mitapivat is a small molecule drug primarily used in the treatment of certain types of hemolytic anemia, particularly pyruvate kinase deficiency. It acts as a pyruvate kinase activator, enhancing the glycolytic pathway and promoting red blood cell survival by improving energy metabolism. The chemical structure of Mitapivat includes a pyrimidine core, which is essential for its biological activity. It is characterized by its ability to increase ATP production in red blood cells, thereby alleviating symptoms associated with anemia. Mitapivat is administered orally and has been shown to have a favorable pharmacokinetic profile, with a relatively long half-life that allows for once-daily dosing. Its safety and efficacy have been evaluated in clinical trials, demonstrating significant improvements in hemoglobin levels and overall patient quality of life. As with any medication, potential side effects may include headache, fatigue, and gastrointestinal disturbances, necessitating monitoring during treatment. Overall, Mitapivat represents a novel therapeutic approach for managing hemolytic anemia linked to pyruvate kinase deficiency.
Formula:C24H26N4O3S
InChI:InChI=1S/C24H26N4O3S/c29-24(28-15-13-27(14-16-28)17-18-6-7-18)20-8-10-21(11-9-20)26-32(30,31)22-5-1-3-19-4-2-12-25-23(19)22/h1-5,8-12,18,26H,6-7,13-17H2
InChI key:XAYGBKHKBBXDAK-UHFFFAOYSA-N
SMILES:C1CC1CN2CCN(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C4=CC=CC5=C4N=CC=C5
Synonyms:
  • N-(4-{[4-(Cyclopropylmethyl)-1-piperazinyl]carbonyl}phenyl)-8-quinolinesulfonamide
  • N-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide
  • PKM2 activator 1020
  • CS-2722
  • 8-Quinolinesulfonamide, N-[4-[[4-(cyclopropylmethyl)-1-piperazinyl]carbonyl]phenyl]-
  • MITAPIVAT;PKM2 ACTIVATOR;CAS 1260075-17-9
  • AG-348
  • PKR-IN-1
  • cas 1260075-17-9
  • AG348;AG348;AG-348
  • See more synonyms
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