CAS 1260533-36-5

Pimitespib

CAS: 1260533-36-5

3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)benzamide

Formula: C₂₅H₂₆N₈O

Purity: 99%

Molecular weight: 454.53

Ref: IN-DG00792725

Benzamide, 3-ethyl-4-[3-(1-methylethyl)-4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-1H-pyrazolo[3,4-b]pyridin-1-yl]-

CAS: 1260533-36-5

Formula: C₂₅H₂₆N₈O

Purity: 98%

Color and Shape: Solid

Molecular weight: 454.5269

Ref: IN-DA000QTU

Pimitespib

CAS: 1260533-36-5

Pimitespib

Formula: C₂₅H₂₆N₈O

Purity: ≥98%

Molecular weight: 454.53

Ref: 54-BUP05368

Pimitespib

CAS: 1260533-36-5

Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).

Formula: C₂₅H₂₆N₈O

Purity: 99.22% - 99.49%

Color and Shape: White Solid

Molecular weight: 454.53

Ref: TM-T16994

TAS-116

CAS: 1260533-36-5

TAS-116 is a cytosolic inhibitor that disrupts the chaperone function of Hsp90. TAS-116 has potent antitumor activity in mouse tumor models and significant cytotoxicity against human stromal tumours. This drug inhibits epidermal growth factor (EGF) receptor signaling, which may be due to its ability to inhibit the ATPase activity of Hsp90. TAS-116 also interacts with the ATPase domain of Hsp90 and binds to two amino acid residues on the surface of the ATPase domain, which are important for substrate binding. These interactions have been shown to be critical for TAS-116’s inhibition of EGF receptor signaling and potent antitumor activity.

Formula: C₂₅H₂₆N₈O

Purity: Min. 95%

Molecular weight: 454.53 g/mol

Ref: 3D-KAC53336