CAS 1262133-64-1

3'-O-(5'-Deoxy-beta-D-ribofuranosyl) Capecitabine

Description:

3'-O-(5'-Deoxy-beta-D-ribofuranosyl) Capecitabine, with the CAS number 1262133-64-1, is a nucleoside analog that is primarily recognized for its role in cancer therapy. This compound is a derivative of capecitabine, which is an oral prodrug of the chemotherapeutic agent 5-fluorouracil (5-FU). The structure of this substance features a ribofuranosyl moiety, which contributes to its biological activity by mimicking natural nucleosides. Its mechanism of action involves selective targeting of tumor cells, where it is enzymatically converted into 5-FU, leading to the inhibition of DNA synthesis and ultimately inducing apoptosis in rapidly dividing cancer cells. The compound exhibits characteristics typical of nucleoside analogs, including solubility in aqueous solutions and the ability to penetrate cellular membranes. Its pharmacokinetics and efficacy are influenced by factors such as metabolic activation and the expression of specific enzymes in tumor tissues. Overall, 3'-O-(5'-Deoxy-beta-D-ribofuranosyl) Capecitabine represents a significant advancement in targeted cancer therapies.

Formula: C₂₀H₃₀FN₃O₉

Synonyms:

• pentyl N-[1-[(2R,3S,5R)-4-[(2S,3S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]oxy-3-hydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate

3'-O-(5-deoxy-β-D-ribofuranosyl) Capecitabine ([1-[5-Deoxy-3-O-(5-deoxy-β-d-ribofuranosyl)-β-d-ribofuranosyl]-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]-carbamic acid pentyl ester)

CAS: 1262133-64-1

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₂₀H₃₀FN₃O₉

Color and Shape: White Off-White Solid

Molecular weight: 475.19661

Ref: 45-1A06660

Capecitabine Impurity 9

CAS: 1262133-64-1

Formula: C₂₀H₃₀FN₃O₉

Color and Shape: White To Off-White Solid

Molecular weight: 475.47

Ref: 4Z-C-358

3’-O-(5’-Deoxy-β-D-ribofuranosyl) Capecitabine

Controlled Product

CAS: 1262133-64-1

Impurity Capecitabine 3-O-BDR Impurity (USP)
Applications Capecitabine (C175650) impurity. Capecitabine 3-O-BDR Impurity (USP).

Formula: C₂₀H₃₀FN₃O₉

Color and Shape: Neat

Molecular weight: 475.47

Ref: TR-D251005

3-o-(5-Deoxy-beta-D-ribofuranosyl) capecitabine

CAS: 1262133-64-1

3-O-(5-Deoxy-beta-D-ribofuranosyl) capecitabine is a potent inhibitor of the kinase that is involved in cancer cell growth and proliferation. It has been shown to induce apoptosis in tumor cells by inhibiting protein synthesis and blocking the cell cycle. This analog of capecitabine has been tested on various human cancer cell lines and has demonstrated significant anti-tumor activity. 3-O-(5-Deoxy-beta-D-ribofuranosyl) capecitabine inhibits the activity of kinases that are essential for cancer cell survival, making it a promising candidate for cancer treatment. Additionally, this compound has been found in urine samples from patients undergoing chemotherapy with capecitabine, suggesting that it may be a useful biomarker for monitoring treatment efficacy.

Formula: C₂₀H₃₀FN₃O₉

Purity: Min. 95%

Molecular weight: 475.5 g/mol

Ref: 3D-MAC13364

Capecitabine 3-O-BDR Impurity

CAS: 1262133-64-1

Formula: C₂₀H₃₀FN₃O₉

Molecular weight: 475.47

Ref: ST-EA-CP-C52010