PKI-tide, with the CAS number 126370-52-3, is a synthetic peptide that serves as a potent inhibitor of protein kinase A (PKA). This peptide is characterized by its ability to selectively bind to the regulatory subunit of PKA, thereby preventing the activation of the enzyme. PKI-tide is typically composed of a sequence of amino acids that confer its specificity and inhibitory properties. It is often utilized in biochemical research to study PKA signaling pathways and their implications in various cellular processes, including metabolism, gene expression, and cell proliferation. The stability and solubility of PKI-tide make it suitable for in vitro experiments, and its role as a research tool has contributed to a deeper understanding of the regulatory mechanisms involving PKA. Additionally, PKI-tide's potential therapeutic applications are being explored, particularly in conditions where PKA activity is dysregulated. Overall, PKI-tide is a valuable compound in the field of molecular biology and pharmacology.

PKI-tide

126370-52-3: PKI-tide, with the CAS number 126370-52-3, is a synthetic peptide that serves as a potent inhibitor of protein kinase A (PKA). This peptide is characterized by its ability to selectively bind to the regulatory subunit of PKA, thereby preventing the activation of the enzyme. PKI-tide is typically composed of a sequence of amino acids that confer its specificity and inhibitory properties. It is often utilized in biochemical research to study PKA signaling pathways and their implications in various cellular processes, including metabolism, gene expression, and cell proliferation. The stability and solubility of PKI-tide make it suitable for in vitro experiments, and its role as a research tool has contributed to a deeper understanding of the regulatory mechanisms involving PKA. Additionally, PKI-tide's potential therapeutic applications are being explored, particularly in conditions where PKA activity is dysregulated. Overall, PKI-tide is a valuable compound in the field of molecular biology and pharmacology.

<p>PKItide demonstrates an inhibitory concentration 50 (IC50) of 0.2 μM against cAMP-dependent protein kinase (cAMP-PK) [1].</p>

PKItide

<p>PKI-tide is a potent, selective inhibitor of the calcium/calmodulin-dependent protein kinase. It inhibits the activity of this enzyme and prevents the activation of other protein kinases by this enzyme. PKI-tide binds to the ATP site of the calcium/calmodulin-dependent protein kinase and blocks the binding of ATP and calmodulin. This inhibition prevents the phosphorylation of target proteins, including myosin light chain in muscle cells.</p>

CAS 126370-52-3

PKI-tide

PKItide

Ref: TM-T81447

PKI-tide

Ref: 3D-FP108936