CAS 126370-52-3

PKI-tide

Description:

PKI-tide, with the CAS number 126370-52-3, is a synthetic peptide that serves as a potent inhibitor of protein kinase A (PKA). This peptide is characterized by its ability to selectively bind to the regulatory subunit of PKA, thereby preventing the activation of the enzyme. PKI-tide is typically composed of a sequence of amino acids that confer its specificity and inhibitory properties. It is often utilized in biochemical research to study PKA signaling pathways and their implications in various cellular processes, including metabolism, gene expression, and cell proliferation. The stability and solubility of PKI-tide make it suitable for in vitro experiments, and its role as a research tool has contributed to a deeper understanding of the regulatory mechanisms involving PKA. Additionally, PKI-tide's potential therapeutic applications are being explored, particularly in conditions where PKA activity is dysregulated. Overall, PKI-tide is a valuable compound in the field of molecular biology and pharmacology.

Formula: C₈₅H₁₄N₃₁O₂₄

InChI: InChI=1S/C85H149N31O24/c1-17-40(8)61(87)77(134)103-44(12)67(124)101-43(11)66(123)98-35-58(119)107-51(24-21-29-96-84(90)91)73(130)116-65(48(16)117)78(135)99-36-59(120)106-50(23-20-28-95-83(88)89)71(128)108-52(25-22-30-97-85(92)93)72(129)109-53(26-27-57(86)118)70(127)102-46(14)69(126)114-63(41(9)18-2)80(137)112-55(32-49-34-94-37-100-49)74(131)110-56(33-60(121)122)76(133)115-64(42(10)19-3)81(138)111-54(31-38(4)5)75(132)113-62(39(6)7)79(136)104-45(13)68(125)105-47(15)82(139)140/h34,37-48,50-56,61-65,117H,17-33,35-36,87H2,1-16H3,(H2,86,118)(H,94,100)(H,98,123)(H,99,135)(H,101,124)(H,102,127)(H,103,134)(H,104,136)(H,105,125)(H,106,120)(H,107,119)(H,108,128)(H,109,129)(H,110,131)(H,111,138)(H,112,137)(H,113,132)(H,114,126)(H,115,133)(H,116,130)(H,121,122)(H,139,140)(H4,88,89,95)(H4,90,91,96)(H4,92,93,97)

InChI key: HXPQOINZWQQAME-UHFFFAOYSA-N

SMILES: CCC(C)C(C(=O)NC(C)C(=O)NC(C)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(C)C(=O)NC(C(C)CC)C(=O)NC(CC1=CNC=N1)C(=O)NC(CC(=O)O)C(=O)NC(C(C)CC)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)O)N

Synonyms:

• H-Ile-Ala-Ala-Gly-Arg-Thr-Gly-Arg-Arg-Gln-Ala-Ile-His-Asp-Ile-Leu-Val-Ala-Ala-OH

PKItide

CAS: 126370-52-3

PKItide demonstrates an inhibitory concentration 50 (IC50) of 0.2 μM against cAMP-dependent protein kinase (cAMP-PK) [1].

Formula: C₈₅H₁₄₉N₃₁O₂₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 1989.29

Ref: TM-T81447

PKI-tide

CAS: 126370-52-3

PKI-tide is a potent, selective inhibitor of the calcium/calmodulin-dependent protein kinase. It inhibits the activity of this enzyme and prevents the activation of other protein kinases by this enzyme. PKI-tide binds to the ATP site of the calcium/calmodulin-dependent protein kinase and blocks the binding of ATP and calmodulin. This inhibition prevents the phosphorylation of target proteins, including myosin light chain in muscle cells.

Formula: C₈₅H₁₄₉N₃₁O₂₄

Purity: Min. 95%

Molecular weight: 1,989.29 g/mol

Ref: 3D-FP108936