CAS 1268524-70-4

JQ 1(+)

Description:

JQ 1(+) is a chemical compound recognized for its role as a selective inhibitor of the enzyme BRD4, which is part of the bromodomain and extraterminal (BET) family of proteins. This compound is notable for its potential applications in cancer research, particularly in targeting various types of malignancies where BRD4 is implicated in the regulation of gene expression and cell proliferation. JQ 1(+) exhibits a high affinity for the bromodomain of BRD4, thereby disrupting its interaction with acetylated histones and influencing transcriptional regulation. The compound is typically characterized by its small molecular size and specific structural features that facilitate its binding to the target protein. Additionally, JQ 1(+) has been studied for its effects on cellular processes, including apoptosis and differentiation, making it a valuable tool in the exploration of therapeutic strategies for diseases associated with dysregulated gene expression. As with many research chemicals, safety and handling precautions should be observed when working with JQ 1(+).

Formula: C₂₃H₂₅ClN₄O₂S

InChI: InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1

InChI key: InChIKey=DNVXATUJJDPFDM-KRWDZBQOSA-N

SMILES: CC=1C2=C(N3C([C@H](CC(OC(C)(C)C)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)SC1C

Synonyms:

• (+)-Jq1
• (S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
• (S)-Jq1
• 1,1-Dimethylethyl (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate
• 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-
• BET domain inhibitor JQ1
• Bromodomain and extra-terminal domain inhibitor JQ1
• JQ1 (BET inhibitor)
• JQ1 (pharmaceutical)
• Jq-1
• tert-Butyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-

CAS: 1268524-70-4

Formula: C₂₃H₂₅ClN₄O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 456.9882

Ref: IN-DA000TCZ

(+)-JQ-1

CAS: 1268524-70-4

(+)-JQ-1

Purity: ≥95%

Molecular weight: 456.99g/mol

Ref: 54-BUP17130

(+)-JQ1

CAS: 1268524-70-4

Ref: 7W-GW0962

(+)-JQ1

CAS: 1268524-70-4

Formula: C₂₃H₂₅ClN₄O₂S

Molecular weight: 456.99

Ref: 4Z-K-031040

(+)-JQ-1

CAS: 1268524-70-4

(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility.

Formula: C₂₃H₂₅ClN₄O₂S

Purity: 97.57% - ≥95%

Color and Shape: Solid

Molecular weight: 456.99

Ref: TM-T2110

(S)-(+)-Tert-butyl 2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

CAS: 1268524-70-4

Applications BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation.
References Li, Z.C., et al.: Nuc. Acids. Res., 41, 277 (2013); Hay, D., et al.: Med. Chem. Comm., 4, 140 (2013);

Formula: C₂₃H₂₅ClN₄O₂S

Color and Shape: Light Yellow Solid

Molecular weight: 456.99

Ref: TR-T117580

(+)-JQ 1

Controlled Product

CAS: 1268524-70-4

Potent BET inhibitor with high specificity for acetyl-lysine recognition motifs found in the BET family (Brd2, Brd3, Brd4, Brdt). Engages with bromodomain pocket and competes with acetylated peptide binding, causing displacement of BET proteins from chromatin and disrupting transcription.  Has been used in clinical trials as chemotherapy and male contraceptive.

Formula: C₂₃H₂₅ClN₄O₂S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 456.99 g/mol

Ref: 3D-FC43273