CAS: 1268524-70-4 - JQ 1(+)

Formula: C₂₃H₂₅ClN₄O₂S

InChI: InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1

InChI key: InChIKey=DNVXATUJJDPFDM-KRWDZBQOSA-N

SMILES: O=C(OC(C)(C)C)CC1N=C(C=2C=CC(Cl)=CC2)C3=C(SC(=C3C)C)N4C(=NN=C41)C

Synonyms:

• (+)-Jq1
• (S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
• (S)-Jq1
• 1,1-Dimethylethyl (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate
• 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-
• BET domain inhibitor JQ1
• Bromodomain and extra-terminal domain inhibitor JQ1
• JQ1 (BET inhibitor)
• JQ1 (pharmaceutical)
• Jq-1
• tert-Butyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-

CAS: 1268524-70-4

• Formula: C₂₃H₂₅ClN₄O₂S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 456.9882

(+)-JQ1

CAS: 1268524-70-4

(+)-JQ-1

CAS: 1268524-70-4

(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with …

• Formula: C₂₃H₂₅ClN₄O₂S
• Purity: 97.57% - ≥95%
• Color and Shape: Solid
• Molecular weight: 456.99

(+)-JQ1

CAS: 1268524-70-4

• Formula: C₂₃H₂₅ClN₄O₂S
• Molecular weight: 456.99

(S)-(+)-Tert-butyl 2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

CAS: 1268524-70-4

Applications BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. References …

• Formula: C₂₃H₂₅ClN₄O₂S
• Color and Shape: Light Yellow Solid
• Molecular weight: 456.99

(+)-JQ 1

CAS: 1268524-70-4

Potent BET inhibitor with high specificity for acetyl-lysine recognition motifs found in the BET family …

• Formula: C₂₃H₂₅ClN₄O₂S
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 456.99 g/mol