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CAS 1268524-70-4

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JQ 1(+)

Description:
JQ 1(+) is a chemical compound recognized for its role as a selective inhibitor of the enzyme BRD4, which is part of the bromodomain and extraterminal (BET) family of proteins. This compound is notable for its potential applications in cancer research, particularly in targeting various types of malignancies where BRD4 is implicated in the regulation of gene expression and cell proliferation. JQ 1(+) exhibits a high affinity for the bromodomain of BRD4, thereby disrupting its interaction with acetylated histones and influencing transcriptional regulation. The compound is typically characterized by its small molecular size and specific structural features that facilitate its binding to the target protein. Additionally, JQ 1(+) has been studied for its effects on cellular processes, including apoptosis and differentiation, making it a valuable tool in the exploration of therapeutic strategies for diseases associated with dysregulated gene expression. As with many research chemicals, safety and handling precautions should be observed when working with JQ 1(+).
Formula:C23H25ClN4O2S
InChI:InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
InChI key:InChIKey=DNVXATUJJDPFDM-KRWDZBQOSA-N
SMILES:CC=1C2=C(N3C([C@H](CC(OC(C)(C)C)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)SC1C
Synonyms:
  • (+)-Jq1
  • (S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
  • (S)-Jq1
  • 1,1-Dimethylethyl (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate
  • 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-
  • BET domain inhibitor JQ1
  • Bromodomain and extra-terminal domain inhibitor JQ1
  • JQ1 (BET inhibitor)
  • JQ1 (pharmaceutical)
  • Jq-1
  • tert-Butyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Found 9 products.