CAS 127-48-0
:Trimethadione
Description:
Trimethadione, with the CAS number 127-48-0, is an organic compound classified as a dione. It is primarily known for its use as an anticonvulsant medication, particularly in the treatment of epilepsy. The chemical structure of trimethadione features a five-membered ring containing two carbonyl groups, which contributes to its pharmacological properties. It is typically a white to off-white crystalline solid that is soluble in organic solvents but has limited solubility in water. Trimethadione acts by modulating neurotransmitter activity in the brain, thereby helping to stabilize electrical activity and prevent seizures. Its pharmacokinetics involve hepatic metabolism, and it is excreted primarily through the urine. While effective, trimethadione may have side effects, including sedation and gastrointestinal disturbances, and its use requires careful monitoring. Due to its potential for toxicity and the availability of alternative treatments, its clinical use has diminished over time. Safety precautions are necessary when handling this compound, as it can pose health risks if not managed properly.
Formula:C6H9NO3
InChI:InChI=1/C6H9NO3/c1-6(2)4(8)7(3)5(9)10-6/h1-3H3
InChI key:InChIKey=IRYJRGCIQBGHIV-UHFFFAOYSA-N
SMILES:O=C1C(C)(C)OC(=O)N1C
Synonyms:- 3,3,5-Trimethyl-2,4-diketooxazolidine
- 3,5,5-Trimethyl-1,3-oxazolidine-2,4-dione
- 3,5,5-Trimethyl-2,4-oxazolidinedione
- Absentol
- Edion
- Epidione
- Epixal
- Minoaleviatin
- Nsc 15799
- Nsc 169503
- Petidion
- Petidon
- Petilep
- Pitmal
- Ptimal
- Tridion
- Tridione
- Tridone
- Trimedal
- Trimetadiona
- Trimetadione
- Trimethadion
- Trimethadione
- Trimethin
- Trimetin
- Trioxanona
- Troxidone
- N-carbamoyl-2-phenylacetamide
- 2,4-Oxazolidinedione, 3,5,5-trimethyl-
- Epidone
- 3,5,5-Trimethyl-2,4-oxazolidinedionenol
- 3,5,5-TRIMETHYLOXAZOLIDINE-2,4-DIONE
- Absetil
- a2297
- 3,5,5-TRIMETHYLOXOZOLIDINE-2,4-DIONE
- Convenixa
- A 2297
- Convexina
- 3,5,5-trimethyl-4-oxazolidinedione
- See more synonyms
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Found 11 products.
TRIMETHADIONE CRS
CAS:TRIMETHADIONE CRSFormula:C6H9NO3Color and Shape:Added ModifiedMolecular weight:143.1406Trimethadione
CAS:Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is a dione-type anticonvulsant with antiepileptic activity.Formula:C6H9NO3Purity:99.67% - >99.99%Color and Shape:Yellow SolidMolecular weight:143.14Trimethadione
CAS:3,5,5-Trimethyloxazolidine-2,4-dioneFormula:C6H9NO3Purity:98%Molecular weight:143.14Trimethadione
CAS:Controlled ProductApplications Trimethadione is an anticonvulsant and antiepileptic agent used in the treatment of pregnant women. Prenatal exposure to anti-epileptic drugs (AEDs) has indicated increased risk of major or minor congenital malformation.
References Ahir, B. et al.: Toxicol. Vitro., 28, 948 (2014); Pastore, V. et al.: Bioorg. Med. Chem., 21, 841 (2013);Formula:C6H9NO3Color and Shape:NeatMolecular weight:143.14Trimethadione
CAS:Trimethadione is an oral hypoglycemic agent. It has been shown to be effective in treating diabetes mellitus, although it has not been approved for that indication by the U.S. Food and Drug Administration (FDA). Trimethadione acts as a competitive inhibitor of the enzyme cytochrome P450 3A4 and other cytochrome P450 enzymes, which may lead to drug interactions. Trimethadione is metabolized by human liver microsomes into trimethadione-N-oxide, which is then converted to trimethadione-N-oxide glucuronide. This compound also inhibits the enzyme dihydropyrimidine dehydrogenase and stimulates glucose oxidation in muscle cells. Trimethadione has been shown to have anti-depressant effects in experimental models of depression, but its efficacy for this use remains unclear.Formula:C6H9NO3Purity:Min. 95%Molecular weight:143.14 g/mol
