CAS 127045-41-4

Pazufloxacin

Description:

Pazufloxacin is a synthetic fluoroquinolone antibiotic characterized by its broad-spectrum antibacterial activity, particularly against Gram-negative and some Gram-positive bacteria. It functions by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. Pazufloxacin is known for its favorable pharmacokinetic properties, including good oral bioavailability and tissue penetration, which enhance its therapeutic efficacy. The compound is typically administered in clinical settings for treating various infections, including respiratory and urinary tract infections. Its chemical structure features a bicyclic core with a fluorine atom, which contributes to its potency and resistance to certain bacterial efflux mechanisms. While pazufloxacin has demonstrated effectiveness in clinical trials, its use may be limited by potential side effects, including gastrointestinal disturbances and, in rare cases, more severe reactions. As with other antibiotics, the emergence of resistance is a concern, necessitating careful consideration of its use in treatment regimens.

Formula: C₁₆H₁₅FN₂O₄

InChI: InChI=1S/C16H15FN2O4/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22/h4-5,7H,2-3,6,18H2,1H3,(H,21,22)/t7-/m0/s1

InChI key: InChIKey=XAGMUUZPGZWTRP-ZETCQYMHSA-N

SMILES: O=C1C=2C3=C(C(=C(F)C2)C4(N)CC4)OC[C@H](C)N3C=C1C(O)=O

Synonyms:

• (-)-(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
• (3S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
• (3s)-10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7h-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid C16H15FN2O4
• 10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (R)-
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)-
• Pazufloxaxin
• T 3761

Pazufloxacin Mesylate

CAS: 127045-41-4, 163680-77-1

Formula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 414.40

Ref: 3B-P1962

(2S)-6-(1-aminocyclopropyl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.0,5,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid

CAS: 127045-41-4

Formula: C₁₆H₁₅FN₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 318.2997

Ref: IN-DA01DQAI

Pazufloxacin

CAS: 127045-41-4

Pazufloxacin (T-3761) is a broad-spectrum fluoroquinolone antibiotic effective against various infections, including strains resistant to other quinolones.

Formula: C₁₆H₁₅FN₂O₄

Color and Shape: Solid

Molecular weight: 318.3

Ref: TM-T75296

Pazufloxacin

CAS: 127045-41-4

Formula: C₁₆H₁₅FN₂O₄

Purity: ≥ 98.0%

Color and Shape: White to light yellow or beige crystalline powder

Molecular weight: 318.30

Ref: 7W-GA3636

Pazufloxacin 100 µg/mL in Acetonitrile

CAS: 127045-41-4

Formula: C₁₆H₁₅FN₂O₄

Color and Shape: Single Solution

Molecular weight: 318.30

Ref: 04-A15896300AL-100

Pazufloxacin

CAS: 127045-41-4

Formula: C₁₆H₁₅FN₂O₄

Color and Shape: Neat

Molecular weight: 318.30

Ref: 04-C15896300

Pazufloxacin

Controlled Product

CAS: 127045-41-4

Applications Pazufloxacin (CAS# 127045-41-4) is a useful research chemical compound.

Formula: C₁₆H₁₅FN₂O₄

Color and Shape: Off-White To Light Yellow

Molecular weight: 318.30

Ref: TR-P212720

Pazufloxacin

CAS: 127045-41-4

Pazufloxacin is an antibacterial agent, which is a synthetic derivative originating from the fluoroquinolone class of compounds. This source categorizes it alongside a group of broad-spectrum antibiotics known for their efficacy against a wide variety of bacterial pathogens. The mode of action of pazufloxacin involves the inhibition of bacterial DNA gyrase and topoisomerase IV. These are essential enzymes for bacterial DNA replication, transcription, repair, and recombination processes. By inhibiting these enzymes, pazufloxacin disrupts the bacterial DNA processes, ultimately leading to cell death.

Formula: C₁₆H₁₅FN₂O₄

Purity: Min. 95%

Molecular weight: 318.3 g/mol

Ref: 3D-AP65124