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CAS 163680-77-1

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Pazufloxaxin methanesulfonate

Description:
Pazufloxacin methanesulfonate is a synthetic fluoroquinolone antibiotic characterized by its broad-spectrum antibacterial activity. It is primarily used in the treatment of various bacterial infections, particularly those caused by Gram-negative and some Gram-positive organisms. The compound exhibits a mechanism of action that involves the inhibition of bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription. Pazufloxacin is known for its favorable pharmacokinetic properties, including good oral bioavailability and tissue penetration, which enhance its therapeutic efficacy. The methanesulfonate salt form improves its solubility and stability, making it suitable for formulation in various dosage forms. Additionally, pazufloxacin has been studied for its potential use in treating respiratory tract infections and urinary tract infections. As with other fluoroquinolones, it may be associated with side effects, including gastrointestinal disturbances and potential effects on tendon health. Overall, pazufloxacin methanesulfonate represents a valuable option in the antibiotic arsenal, particularly in the context of increasing antibiotic resistance.
Formula:C17H19FN2O7S
InChI:InChI=1/C16H15FN2O4.CH4O3S/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22;1-5(2,3)4/h4-5,7H,2-3,6,18H2,1H3,(H,21,22);1H3,(H,2,3,4)/t7-;/m0./s1
InChI key:InChIKey=UDHGFPATQWQARM-FJXQXJEOSA-N
SMILES:O=C1C=2C3=C(C(=C(F)C2)C4(N)CC4)OC[C@H](C)N3C=C1C(O)=O.S(C)(=O)(=O)O
Synonyms:
  • (3S)-10-(1-Aminocyclopropyl)-9-Fluoro-2,3-Dihydro-3-Methyl-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid Methanesulfonate
  • (3S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid methanesulfonate
  • (S)-(-)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine -6-carboxylic acid monomethanesulfonate
  • 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1)
  • 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, monomethanesulfonate
  • 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)-, monomethanesulfonate
  • 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, monomethanesulfonate (9CI)
  • Pasil
  • Pazucross
  • Pazufloxacin Mesilate
  • See more synonyms
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