CAS 127134-13-8

DABCYL-GAMMA-ABU-SER-GLN-ASN-TYR-PRO-ILE-VAL-GLN-EDANS

Description:

DABCYL-GAMMA-ABU-SER-GLN-ASN-TYR-PRO-ILE-VAL-GLN-EDANS is a peptide-based chemical compound commonly used in biochemical research, particularly in fluorescence resonance energy transfer (FRET) applications. This compound consists of a donor (EDANS) and an acceptor (DABCYL) moiety, which are separated by a peptide sequence. The presence of these two fluorophores allows for the study of molecular interactions and conformational changes in proteins or nucleic acids. The peptide sequence includes various amino acids, contributing to its structural and functional properties. DABCYL acts as a quencher, absorbing energy from the excited state of EDANS, which emits fluorescence when not in proximity to the quencher. The stability and solubility of this compound are influenced by the specific amino acid composition and the overall peptide structure. Its applications extend to monitoring enzymatic activity, studying protein folding, and investigating cellular processes, making it a valuable tool in molecular biology and biochemistry.

Formula: C₇₃H₉₇N₁₇O₁₈S

Synonyms:

• 4-(4-Dimethylaminophenylazo)Benzoyl-Gamma-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-5-[(2-Aminoethyl)Amino]-Naphthalene-1-Sulfonic Acid
• Hiv Protease Fret Substrate I
• Dabcyl-Gaba-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Edans
• DABCYL-GAMMA-ABU-SER-GLN-ASN-TYR-PRO-ILE-VAL-GLN-EDANS
• DABCYL-γ-Abu-SQNYPIVQ-EDANS
• DABCYL-gamma-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS trifluoroacetate salt
• L-Glutamamide,N-[4-[[4-[[4-(dimethylamino)phenyl]azo]benzoyl]amino]-1-oxobutyl]-L-seryl-L-glutaminyl-L-asparaginyl-L-tyrosyl-L-prolyl-L-isoleucyl-L-valyl-N1-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-
• DABCYL-γ-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS trifluoroacetate salt
• DABCYL-g-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS

DABCYL-γ-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS

CAS: 127134-13-8

The fluorogenic HIV-1 protease substrate DABCYL-Gaba-SQNYPIVQ-EDANS consists of an octapeptide with a fluorescent donor (EDANS) and a quenching acceptor (DABCYL), attached at the COOH- and NH₂-termini. The γ-Abu spacer was inserted to avoid potential steric hindrance of substrate binding by the bulky acceptor. This FRET substrate is cleaved by the HIV-1 protease at the Tyr-Pro bond which results in a time-dependent increase in fluorescence intensity; excitation at 340 nm, emission at 490 nm.

Formula: C₇₃H₉₇N₁₇O₁₈S

Purity: > 95%

Molecular weight: 1532.74

Ref: 01-4030716

Dabcyl-γ-abu-ser-gln-asn-tyr-pro-ile-val-gln-edans trifluoroacetate salt

CAS: 127134-13-8

Formula: C₇₃H₉₇N₁₇O₁₈S

Molecular weight: 1532.7194

Ref: IN-DA000WPO

Dabcyl-γ-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Edans

CAS: 127134-13-8

Dabcyl-γ-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Edans is a bifunctional peptide that inhibits HIV protease. The peptide binds to the active site of the enzyme and blocks access to the catalytic triad, inhibiting its function. This peptide has been shown to inhibit viral life in human cells infected with HIV type 1 (HIV1), as well as virions, which are released into the bloodstream. Dabcyl is a small molecule inhibitor of HIV1 protease that also inhibits cellular proteases. It has been shown to inhibit viral life in human T cell lines (THP1) and other cells infected with HIV type 1 (HIV1).

Formula: C₇₃H₉₇N₁₇O₁₈S

Purity: Min. 95%

Molecular weight: 1,532.75 g/mol

Ref: 3D-SFQ-3763-PI

DABCYL-γ-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS trifluoroacetate salt

CAS: 127134-13-8

Please enquire for more information about DABCYL-gamma-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₇₃H₉₇N₁₇O₁₈S

Purity: Min. 95%

Molecular weight: 1,532.72 g/mol

Ref: 3D-FD110893