CAS 127254-12-0: Sitafloxacin

Description: Sitafloxacin is a synthetic fluoroquinolone antibiotic characterized by its broad-spectrum antibacterial activity, particularly against Gram-negative and some Gram-positive bacteria. It functions by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription. Sitafloxacin is known for its favorable pharmacokinetic properties, including good oral bioavailability and tissue penetration, which enhance its effectiveness in treating various infections. The compound is typically administered in the form of its hydrochloride salt, which improves its solubility. Its chemical structure features a bicyclic core with a fluorine atom, contributing to its potency and resistance to certain bacterial efflux mechanisms. Sitafloxacin is primarily used in the treatment of respiratory and urinary tract infections, and it has shown efficacy against strains resistant to other antibiotics. However, like other fluoroquinolones, it may be associated with side effects, including gastrointestinal disturbances and potential effects on tendon health. As with any antibiotic, appropriate use is essential to minimize the risk of resistance development.

Formula: C₁₉H₁₈ClF₂N₃O₃

InChI: InChI=1S/C19H18ClF2N3O3/c20-14-15-8(17(26)9(18(27)28)5-25(15)12-4-10(12)21)3-11(22)16(14)24-6-13(23)19(7-24)1-2-19/h3,5,10,12-13H,1-2,4,6-7,23H2,(H,27,28)/t10-,12+,13+/m0/s1

InChI key: InChIKey=PNUZDKCDAWUEGK-CYZMBNFOSA-N

SMILES: O=C(O)C1=CN(C2=C(Cl)C(=C(F)C=C2C1=O)N3CC(N)C4(C3)CC4)C5CC5F

Synonyms:

• 3-Quinolinecarboxylic acid, 7-(7-amino-5-azaspiro[2.4]hept-5-yl)-8-chloro-6-fluoro-1-(2-fluorocyclopropyl)-1,4-dihydro-4-oxo-, [1R-[1α(S*),2α]]-
• 3-Quinolinecarboxylic acid, 7-[(7S)-7-amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-
• 5-Azaspiro[2.4]heptane, 3-quinolinecarboxylic acid deriv.
• 7-[(4S)-4-Amino-6-azaspiro[2.4]heptan-6-yl]-8-chloro-6-fluoro-1-[(2S)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid
• 7-[(7S)-7-Amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
• 7-[(7S)-7-amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• 7-[(7S)-7-amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• DU 6859a
• Du 6859
• Gracevit
• Spifloxacin

3-Quinolinecarboxylic acid, 7-[(7S)-7-amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-

CAS: 127254-12-0

• Formula: C₁₉H₁₈ClF₂N₃O₃
• Purity: 98.5%
• Color and Shape: Solid
• Molecular weight: 409.8143

Sitafloxacin-d4

CAS: 127254-12-0

• Formula: C₁₉H₁₄D₄ClF₂N₃O₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 413.84

Sitafloxacin

CAS: 127254-12-0

Sitafloxacin: potent broad-spectrum oral fluoroquinolone effective against resistant strains.

• Formula: C₁₉H₁₈ClF₂N₃O₃
• Purity: 99.2%
• Color and Shape: Solid
• Molecular weight: 409.81

Sitafloxacin

CAS: 127254-12-0

• Purity: ≥98%
• Molecular weight: 409.81g/mol

Sitafloxacin

CAS: 127254-12-0

Sitafloxacin

CAS: 127254-12-0

• Formula: C₁₉H₁₈ClF₂N₃O₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 409.82

Sitafloxacin 100 µg/mL in Acetonitrile

CAS: 127254-12-0

• Formula: C₁₉H₁₈ClF₂N₃O₃
• Color and Shape: Single Solution
• Molecular weight: 409.81

Sitafloxacin

CAS: 127254-12-0

• Formula: C₁₉H₁₈ClF₂N₃O₃
• Color and Shape: Neat
• Molecular weight: 409.81

Sitafloxacin

CAS: 127254-12-0

Please enquire for more information about Sitafloxacin including the price, delivery time and more detailed …

• Formula: C₁₉H₁₈ClF₂N₃O₃
• Purity: Min. 95%
• Color and Shape: Solid
• Molecular weight: 409.81 g/mol